Rat Peroxisome Proliferator-activated receptor γ,PPAR-γ ELISA Kit

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.

1. ET-1 stimulates miR-27a/b expression by activation of the NF-kappaB pathway, which in turn results in PPARgamma reduction and contributes to ET-1-induced pulmonary artery smooth muscle cell proliferation. PMID: 28484848
2. These results taken together suggest that PPARgamma activation in Sertoli cells. PMID: 28432465
3. Overexpression of TUSC7 inhibited the inflammation caused by microglia activation via miR-449a up-regulating PPAR-gamma. PMID: 30119293
4. nesfatin-1 stimulated vascular smooth muscle cells proliferation, migration and neointimal hyperplasia by elevating MMP2/MMP-9 levels and inhibiting PPARgamma gene expression. PMID: 29604590
5. These results indicate that PPAR-gamma negatively regulates the differentiation of Bone marrow mesenchymal stem cells into fibroblasts. PMID: 29568896
6. these results suggest that tacrolimus may protect rats from MIRI through activation of the PPARgamma/PI3K/Akt pathway. PMID: 29488613
7. Curcumin treatment upregulated the PPARgamma activity and expression level of HO1 which were suppressed in lung tissue of neonatal ALI rats. PMID: 29480285
8. miRNA-27 play essential roles in regulating osteoblast differentiation and bone apoptosis by arthritis through PPARgamma expression in vivo and in vitro model. PMID: 29393373
9. The present study demonstrates that miR-27b regulates chondrocyte hypertrophy in part by targetting Ppargamma2, and that miR-27b may have important therapeutic implications in cartilage diseases PMID: 29187585
10. L-Carnitine alleviated epithelial mesenchymal transformation-associated renal fibrosis caused by perfluorooctanesulfonate through a Sirt1- and PPARgamma-dependent mechanism. PMID: 28973641
11. Telmisartan prevented learning/memory deficits in spontaneously hypertensive rat model of vascular dementia via PPAR-gamma signaling pathway. PMID: 29241675
12. The s identify an endogenous role for PPARalpha in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. They also suggest PPARalpha as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits PMID: 29183319
13. miR-27a up-regulation could inhibit adipogenesis and promote osteogenesis by directly targeting PPARgamma and GREM1. PMID: 27910957
14. PPAR-gamma activation by reducing proinflammatory cytokines, apoptosis, and necroptosis in the myocardium prevents septic myocardial dysfunction. PMID: 28845215
15. leptin signal with suppressing of PPAR-gamma mRNA expression in rat's adipose and liver tissues can result in lipolysis instead of lipogenesis. PMID: 28838346
16. the altered expressions of PPARgamma, TRPC1 and TRPC6 in the pulmonary artery located in the lungs of newborn rats with Persistent pulmonary hypertension of the newborn (PPHN) suggested that these proteins may be important mediators of PPHN. PMID: 28627661
17. Rosiglitazone can increase thrombin-induced microglial phagocytosis, by a mechanism possibly involved in the increase of proliferator-activated receptor-gamma (PPARgamma) and cluster of differentiation 36 through the PPARgamma pathway, which may provide a new option for cerebral hemorrhage treatment. PMID: 28445772
18. Further studies showed that miR-27a negatively regulated PPARgamma expression by binding to the 3'-untranslated region of rat PPARgamma. These findings suggest that specific reduction of renal miR-27a decreases renal fibrosis, which may be explained in part by its regulation of PPARgamma. PMID: 27184517
19. Our results clearly demonstrated that the administration of ROSG after SCI reduced autophagy and promoted functional recovery after SCI in rats. PMID: 28433567
20. Data show that cyclin-dependent kinase 5 (CDK5) siRNA inhibits epithelial-to-mesenchymal transition (EMT) via extracellular signal-regulated kinase 1/2 (ERK1/2)/peroxisome proliferator-activated receptor gamma (PPRAgamma) pathway in high glucose cultured renal tubular cell line NRK-52E cells. PMID: 27145370
21. Agonists have been developed that simultaneously activate the three PPAR receptors (PPARalpha, gamma and delta) in the hope that the beneficial effects can be harnessed while avoiding some of the negative side effects. In this study, the hepatic effects of a discontinued PPAR-pan agonist (a triple agonist of PPAR-alpha, -gamma, and -delta), was investigated after dietary treatment of male Sprague-Dawley (SD) rats. PMID: 26654758
22. We propose a novel role of the miR-27a/PPARgamma/beta-catenin axis in fostering the progression toward more deteriorated podocyte injury in diabetic nephropathy (DN). Targeting miR-27a could be a potential therapeutic approach for DN. PMID: 28277542
23. PPAR-gamma agonistpioglitazone prevented the development of LV fibrosis and heart failure in a rat model, at least partly due to attenuated Wnt-beta-catenin signaling. PMID: 27046338
24. data suggest that down-regulation of PPARgamma with inhibitory effects on COX-2 and StAR expression is important for inducing normal ovulation and early luteal development in rats PMID: 28529269
25. PPARgamma transcriptionally regulates PNLIP gene expression. PMID: 27663184
26. Hypercholesterolemia-induced decreased myocardial cell membrane fluidity may contribute to the increased susceptibility to cardiac injury, and maybe reversed using PPAR-gamma agonists. PMID: 26679939
27. Our findings indicate that this newly identified SIRT3/beta-catenin/PPAR-gamma axis will provide novel insight into the understanding of the mechanism of transdifferentiation of cardiac fibroblasts to myofibroblasts. PMID: 28760678
28. Consumption of a lard-rich diet for 12 wk worsened liver injury and increased hepatic PPARalpha and PPARgamma expression in endotoxemic rats. PMID: 28550910
29. a sedentary lifestyle and vitamin D deficiency accelerated the occurrence of metabolic syndrome probably by decreasing the expression of nuclear receptor PPARgamma PMID: 28336108
30. Low PPAR gamma expression is associated with hepatic fibrosis. PMID: 28177765
31. postnatal functions of PPARgamma PMID: 27505464
32. CTRP6 improves PPARgamma activation and alleviates AngII-induced hypertension and vascular endothelial dysfunction PMID: 27871858
33. Data indicate that an increase in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression in the myocardium receiving apigenin reinforces the role of PPAR-gamma pathway activation in the cardioprotective effects of apigenin. PMID: 28375162
34. Sodium tanshinone IIA sulfonate can prevent hypoxia-mediated increases in intracellular calcium homeostasis and cell proliferation, by targeting and restoring the hypoxia-inhibited PKG-PPAR-gamma signaling pathway in pulmonary artery smooth muscle cells. PMID: 27194472
35. This study investigates the role of peroxisome proliferator-activated receptor (PPAR)-gamma in hypothalamus-pituitary-adrenal axis A axis hyperactivity in diabetic rats. PMID: 27725163
36. Thus, it could be concluded that EPO and IGF1 possessed a potent synergism in promoting osteogenic differentiation, and the synergism was mainly attributed to co-regulation of different osteogenic regulators PPARgamma and TAZ, which were targeted genes of EPO and IGF1 respectively. PMID: 27422606
37. Huangkui capsule activates PPARalpha/gamma and attenuates endoplasmic reticulum stress in diabetic nephropathy. PMID: 27224243
38. esveratrol can correct fat formation and storage imbalance status by up-regulating FSP27 and down-regulating PPAR-gamma expression level, ameliorating insulin sensitivity. PMID: 27716232
39. Fenretinide might be a potent antihypertensive agent that works by suppressing inflammation via activating PPARgamma. PMID: 27843299
40. Data suggest that PPARgamma plays role in protecting skeletal muscle cells against oxidative stress/myositis caused by excessive exercise or oxidants; PPARgamma appears to exert anti-inflammatory and anti-oxidant activity via inhibition of the MAP kinase/NFkappaB signaling pathway. PMID: 27718123
41. The sensitivity of aortic rings to alpha-1 and alpha-2 adrenoceptors was decreased in the presence of pioglitazone and/or losartan in diabetic and hypertensive rats. Concomitant use of PPAR-gamma agonists, thiazolidinediones, and angiotensin receptor blockers may be effective treatment for diabetes and hypertension. PMID: 27149161
42. Telmisartan improved the hyperglycemia-induced cardiac fibrosis through the PPARdelta/STAT3 pathway. PMID: 27519769
43. production of intracellular ROS and MMP modulated by MPP(+) was decreased by PPARgamma and Nurr1 agonists' treatment alone and in the combined form. PMID: 27435855
44. Reduction of PPAR-gamma expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance. PMID: 27538526
45. PPARgamma agonist, through PPARgamma-dependent mechanism and via decreasing p-Drp1(Ser616) expression, can exert anti-oxidative and anti-apoptotic effects against ischemic neuronal injury. PMID: 27175924
46. PPARgamma level was down-regulated by miR-383 overexpression, and up-regulated by miR-383 inhibition both in rat model of middle cerebral artery occlusion and in primary culture cells. PMID: 27607022
47. This study demonstrated that Axonal PPARgamma promotes neuronal regeneration after injury. PMID: 26446277
48. Exercise training increases vascular PPAR-gamma expression in ApoE(-/-) mice that could potentially underlie training-related beneficial effects on atherosclerosis PMID: 26467845
49. The aim of this study is to investigate whether levels of peroxisome proliferator-activated receptors (PPARs) in muscle and transcription of PPAR target genes are affected by long-term dehydroepiandrosterone administration. PMID: 26406917
50. Data show that dihydrotestosterone may affect ovarian follicular maturation by altering granulosa cell proliferation through the regulation of PPAR gamma (PPARgamma) dependent PTEN phosphohydrolase (PTEN)/akt proto-Oncogene protein (p-Akt) expression. PMID: 26674985

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Nucleus. Cytoplasm.

Nuclear hormone receptor family, NR1 subfamily

Highest expression in adipose tissue.

KEGG: rno:25664

STRING: 10116.ENSRNOP00000012137

UniGene: Rn.23443