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  4. Recombinant Rat Peroxisome proliferator-activated receptor gamma (Pparg)

Recombinant Rat Peroxisome proliferator-activated receptor gamma (Pparg)

  • 货号：
    CSB-YP018424RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018424RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018424RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018424RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018424RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Pparg; Nr1c3; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-505
  • 氨基酸序列
    MGETLGDPPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMDDHSHSF DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKVLQKMTDL RQIVTEHVQL LHVIKKTETD MSLHPLLQEI YKDLY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.
  • 基因功能参考文献：
    1. ET-1 stimulates miR-27a/b expression by activation of the NF-kappaB pathway, which in turn results in PPARgamma reduction and contributes to ET-1-induced pulmonary artery smooth muscle cell proliferation. PMID: 28484848
    2. These results taken together suggest that PPARgamma activation in Sertoli cells. PMID: 28432465
    3. Overexpression of TUSC7 inhibited the inflammation caused by microglia activation via miR-449a up-regulating PPAR-gamma. PMID: 30119293
    4. nesfatin-1 stimulated vascular smooth muscle cells proliferation, migration and neointimal hyperplasia by elevating MMP2/MMP-9 levels and inhibiting PPARgamma gene expression. PMID: 29604590
    5. These results indicate that PPAR-gamma negatively regulates the differentiation of Bone marrow mesenchymal stem cells into fibroblasts. PMID: 29568896
    6. these results suggest that tacrolimus may protect rats from MIRI through activation of the PPARgamma/PI3K/Akt pathway. PMID: 29488613
    7. Curcumin treatment upregulated the PPARgamma activity and expression level of HO1 which were suppressed in lung tissue of neonatal ALI rats. PMID: 29480285
    8. miRNA-27 play essential roles in regulating osteoblast differentiation and bone apoptosis by arthritis through PPARgamma expression in vivo and in vitro model. PMID: 29393373
    9. The present study demonstrates that miR-27b regulates chondrocyte hypertrophy in part by targetting Ppargamma2, and that miR-27b may have important therapeutic implications in cartilage diseases PMID: 29187585
    10. L-Carnitine alleviated epithelial mesenchymal transformation-associated renal fibrosis caused by perfluorooctanesulfonate through a Sirt1- and PPARgamma-dependent mechanism. PMID: 28973641
    11. Telmisartan prevented learning/memory deficits in spontaneously hypertensive rat model of vascular dementia via PPAR-gamma signaling pathway. PMID: 29241675
    12. The s identify an endogenous role for PPARalpha in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. They also suggest PPARalpha as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits PMID: 29183319
    13. miR-27a up-regulation could inhibit adipogenesis and promote osteogenesis by directly targeting PPARgamma and GREM1. PMID: 27910957
    14. PPAR-gamma activation by reducing proinflammatory cytokines, apoptosis, and necroptosis in the myocardium prevents septic myocardial dysfunction. PMID: 28845215
    15. leptin signal with suppressing of PPAR-gamma mRNA expression in rat's adipose and liver tissues can result in lipolysis instead of lipogenesis. PMID: 28838346
    16. the altered expressions of PPARgamma, TRPC1 and TRPC6 in the pulmonary artery located in the lungs of newborn rats with Persistent pulmonary hypertension of the newborn (PPHN) suggested that these proteins may be important mediators of PPHN. PMID: 28627661
    17. Rosiglitazone can increase thrombin-induced microglial phagocytosis, by a mechanism possibly involved in the increase of proliferator-activated receptor-gamma (PPARgamma) and cluster of differentiation 36 through the PPARgamma pathway, which may provide a new option for cerebral hemorrhage treatment. PMID: 28445772
    18. Further studies showed that miR-27a negatively regulated PPARgamma expression by binding to the 3'-untranslated region of rat PPARgamma. These findings suggest that specific reduction of renal miR-27a decreases renal fibrosis, which may be explained in part by its regulation of PPARgamma. PMID: 27184517
    19. Our results clearly demonstrated that the administration of ROSG after SCI reduced autophagy and promoted functional recovery after SCI in rats. PMID: 28433567
    20. Data show that cyclin-dependent kinase 5 (CDK5) siRNA inhibits epithelial-to-mesenchymal transition (EMT) via extracellular signal-regulated kinase 1/2 (ERK1/2)/peroxisome proliferator-activated receptor gamma (PPRAgamma) pathway in high glucose cultured renal tubular cell line NRK-52E cells. PMID: 27145370
    21. Agonists have been developed that simultaneously activate the three PPAR receptors (PPARalpha, gamma and delta) in the hope that the beneficial effects can be harnessed while avoiding some of the negative side effects. In this study, the hepatic effects of a discontinued PPAR-pan agonist (a triple agonist of PPAR-alpha, -gamma, and -delta), was investigated after dietary treatment of male Sprague-Dawley (SD) rats. PMID: 26654758
    22. We propose a novel role of the miR-27a/PPARgamma/beta-catenin axis in fostering the progression toward more deteriorated podocyte injury in diabetic nephropathy (DN). Targeting miR-27a could be a potential therapeutic approach for DN. PMID: 28277542
    23. PPAR-gamma agonistpioglitazone prevented the development of LV fibrosis and heart failure in a rat model, at least partly due to attenuated Wnt-beta-catenin signaling. PMID: 27046338
    24. data suggest that down-regulation of PPARgamma with inhibitory effects on COX-2 and StAR expression is important for inducing normal ovulation and early luteal development in rats PMID: 28529269
    25. PPARgamma transcriptionally regulates PNLIP gene expression. PMID: 27663184
    26. Hypercholesterolemia-induced decreased myocardial cell membrane fluidity may contribute to the increased susceptibility to cardiac injury, and maybe reversed using PPAR-gamma agonists. PMID: 26679939
    27. Our findings indicate that this newly identified SIRT3/beta-catenin/PPAR-gamma axis will provide novel insight into the understanding of the mechanism of transdifferentiation of cardiac fibroblasts to myofibroblasts. PMID: 28760678
    28. Consumption of a lard-rich diet for 12 wk worsened liver injury and increased hepatic PPARalpha and PPARgamma expression in endotoxemic rats. PMID: 28550910
    29. a sedentary lifestyle and vitamin D deficiency accelerated the occurrence of metabolic syndrome probably by decreasing the expression of nuclear receptor PPARgamma PMID: 28336108
    30. Low PPAR gamma expression is associated with hepatic fibrosis. PMID: 28177765
    31. postnatal functions of PPARgamma PMID: 27505464
    32. CTRP6 improves PPARgamma activation and alleviates AngII-induced hypertension and vascular endothelial dysfunction PMID: 27871858
    33. Data indicate that an increase in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression in the myocardium receiving apigenin reinforces the role of PPAR-gamma pathway activation in the cardioprotective effects of apigenin. PMID: 28375162
    34. Sodium tanshinone IIA sulfonate can prevent hypoxia-mediated increases in intracellular calcium homeostasis and cell proliferation, by targeting and restoring the hypoxia-inhibited PKG-PPAR-gamma signaling pathway in pulmonary artery smooth muscle cells. PMID: 27194472
    35. This study investigates the role of peroxisome proliferator-activated receptor (PPAR)-gamma in hypothalamus-pituitary-adrenal axis A axis hyperactivity in diabetic rats. PMID: 27725163
    36. Thus, it could be concluded that EPO and IGF1 possessed a potent synergism in promoting osteogenic differentiation, and the synergism was mainly attributed to co-regulation of different osteogenic regulators PPARgamma and TAZ, which were targeted genes of EPO and IGF1 respectively. PMID: 27422606
    37. Huangkui capsule activates PPARalpha/gamma and attenuates endoplasmic reticulum stress in diabetic nephropathy. PMID: 27224243
    38. esveratrol can correct fat formation and storage imbalance status by up-regulating FSP27 and down-regulating PPAR-gamma expression level, ameliorating insulin sensitivity. PMID: 27716232
    39. Fenretinide might be a potent antihypertensive agent that works by suppressing inflammation via activating PPARgamma. PMID: 27843299
    40. Data suggest that PPARgamma plays role in protecting skeletal muscle cells against oxidative stress/myositis caused by excessive exercise or oxidants; PPARgamma appears to exert anti-inflammatory and anti-oxidant activity via inhibition of the MAP kinase/NFkappaB signaling pathway. PMID: 27718123
    41. The sensitivity of aortic rings to alpha-1 and alpha-2 adrenoceptors was decreased in the presence of pioglitazone and/or losartan in diabetic and hypertensive rats. Concomitant use of PPAR-gamma agonists, thiazolidinediones, and angiotensin receptor blockers may be effective treatment for diabetes and hypertension. PMID: 27149161
    42. Telmisartan improved the hyperglycemia-induced cardiac fibrosis through the PPARdelta/STAT3 pathway. PMID: 27519769
    43. production of intracellular ROS and MMP modulated by MPP(+) was decreased by PPARgamma and Nurr1 agonists' treatment alone and in the combined form. PMID: 27435855
    44. Reduction of PPAR-gamma expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance. PMID: 27538526
    45. PPARgamma agonist, through PPARgamma-dependent mechanism and via decreasing p-Drp1(Ser616) expression, can exert anti-oxidative and anti-apoptotic effects against ischemic neuronal injury. PMID: 27175924
    46. PPARgamma level was down-regulated by miR-383 overexpression, and up-regulated by miR-383 inhibition both in rat model of middle cerebral artery occlusion and in primary culture cells. PMID: 27607022
    47. This study demonstrated that Axonal PPARgamma promotes neuronal regeneration after injury. PMID: 26446277
    48. Exercise training increases vascular PPAR-gamma expression in ApoE(-/-) mice that could potentially underlie training-related beneficial effects on atherosclerosis PMID: 26467845
    49. The aim of this study is to investigate whether levels of peroxisome proliferator-activated receptors (PPARs) in muscle and transcription of PPAR target genes are affected by long-term dehydroepiandrosterone administration. PMID: 26406917
    50. Data show that dihydrotestosterone may affect ovarian follicular maturation by altering granulosa cell proliferation through the regulation of PPAR gamma (PPARgamma) dependent PTEN phosphohydrolase (PTEN)/akt proto-Oncogene protein (p-Akt) expression. PMID: 26674985

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 组织特异性：
    Highest expression in adipose tissue.
  • 数据库链接：

    KEGG: rno:25664

    STRING: 10116.ENSRNOP00000012137

    UniGene: Rn.23443