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Rat transforming growth factor α,TGF-α ELISA Kit

  • 中文名称：
    大鼠转化生长因子α(TGF-α)酶联免疫试剂盒
  • 货号：
    CSB-E07289r
  • 规格：
    96T/48T
  • 价格：
    ￥3900/￥2500
  • 其他：

产品详情

  • 产品描述：

    The Rat Transforming Growth Factor α (TGF-α) ELISA Kit is designed for the accurate and reliable detection of transforming growth factor alpha (TGF-α) in serum, plasma, and tissue homogenates of Rattus norvegicus (rat) samples.

    The assay is based on the quantitative sandwich method and has a detection range of 7.8 pg/ml to 500 pg/ml, with a sensitivity of 1.95 pg/ml. With a quick assay time of 1-5 hours and a sample volume of 50-100ul, this kit provides an efficient and time-saving solution for researchers in the signal transduction field.

    The detection wavelength for this kit is 450 nm, providing high sensitivity and specificity for the measurement of TGF-α in rat samples. The Rat Transforming Growth Factor α, TGF-α ELISA Kit is based on a sandwich assay principle that provides high specificity and accuracy for the detection of this protein.

    The Rat Transforming Growth Factor α (TGF-α) ELISA Kit is ideal for researchers studying signal transduction,cell migration, growth, and differentiation. Whether you are investigating the role of TGF-α in the development of cancer or its potential as a therapeutic target, this kit offers a reliable and accurate means of quantifying TGF-α levels in your samples.

  • 别名：
    Tgfa ELISA Kit; Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha ELISA Kit; TGF-alpha ELISA Kit; EGF-like TGF ELISA Kit; ETGF ELISA Kit; TGF type 1)] ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    7.8 pg/ml-500pg/ml
  • 灵敏度：
    1.95 pg/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 线性度：
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
  • 基因功能参考文献：
    1. 5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. PMID: 26804134
    2. Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. PMID: 24595367
    3. results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion PMID: 12021046
    4. A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. PMID: 12029622
    5. TGF-alpha exerts a neuroprotective action against NMDA toxicity, in which Erk1/2 activation plays a key role PMID: 12771152
    6. TGF-alpha, laminin, and fibronectin are required for ovary follicle development and maturation PMID: 14656002
    7. TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells. PMID: 15353178
    8. study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis PMID: 17968906
    9. mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID: 19237431
    10. TGF-alpha has the ability to suppress anoikis of intestinal epithelial cells, at least in part, by reverting the loss of c-Src activity and Bcl-X(L) expression induced by detachment from the ECM. PMID: 11487584

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  • 亚细胞定位：
    [Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: rno:24827

    STRING: 10116.ENSRNOP00000054248

    UniGene: Rn.9952