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  4. Recombinant Human Persephin protein (PSPN), partial (Active)

Recombinant Human Persephin protein (PSPN), partial (Active)

In Stock
  • 货号：
    CSB-AP002951HU
  • 规格：
    ￥852
  • 图片：
  • 其他：

产品详情

  • 纯度：
    >97% as determined by SDS-PAGE.
  • 内毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TT medullary thyroid cancer cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x105 IU/mg.
  • 基因名：
    PSPN
  • Uniprot No.：
  • 别名：
    PSPN; Persephin; PSP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.Coli
  • 分子量：
    10.3 kDa
  • 表达区域：
    61-156aa
  • 氨基酸序列
    ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
  • 基因功能参考文献：
    1. Results suggested that PSPN is a possible key regulator of oral squamous cell carcinoma (OSCC) progression via PSPN-RET-mitogen-activated protein kinase activation and that PSPN overexpression may have diagnostic potential for OSCC. PMID: 24375483
    2. Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex. PMID: 20350599
    3. Persephin/GFRalpha4 is unable to recruit RET protein into lipid rafts. PMID: 15225646
    4. The results obtained suggest the involvement of NTN, PSP, and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons. PMID: 15829225
    5. No differences were found in the allelic frequencies of the variants or in the haplotype distribution between Hirschsprung's disease patients & controls, nor to any demographic/clinical parameters within the group of patients. PMID: 18970938

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family, GDNF subfamily
  • 数据库链接：

    HGNC: 9579

    OMIM: 602921

    KEGG: hsa:5623

    STRING: 9606.ENSP00000245810

    UniGene: Hs.248159