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  4. Recombinant Human Interleukin-31 (IL31) (Active)

Recombinant Human Interleukin-31 (IL31) (Active)

Unavailable
  • 货号：
    CSB-AP004631HU
  • 规格：
    ￥1740
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 内毒素：
    Less than 0.01 EU/µg as determined by LAL method.
  • 生物活性：
    The ED50 as determined by inducing STAT3 activation in U87 MG human glioblastoma/astrocytoma cells is less than 45 ng/mL.
  • 基因名：
  • Uniprot No.：
  • 别名：
    IL 31; IL-31; IL31; IL31_HUMAN; Interleukin 31; Interleukin-31
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    15.8 kDa
  • 表达区域：
    24-164aa
  • 氨基酸序列
    SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages.
  • 基因功能参考文献：
    1. Eosinophils are a major source of IL-31 in bullous pemphigoid and this cytokine may contribute to itch in these patients. PMID: 29693698
    2. Lung cancer patients homozygous CC for rs7977932 or carried the G allele of rs4758680 had significantly poorer prognoses compared to those who did not have these genotype; the rs7977932 CC genotype was significantly associated with metastasis and poor survival status in lung adenocarcinoma PMID: 29791232
    3. The findings suggest that rs7977932 and rs4758680 of IL-31 may be associated with the development and progression of the epithelial ovarian cancer in the Chinese population. PMID: 29484036
    4. this study shows that decreased serum levels of IL-31 correlate in treated patients with Relapsing-Remitting Multiple Sclerosis PMID: 29050818
    5. review: in-depth overview of the role of IL-31 in chronic skin diseases and the possible diagnostic and therapeutic applications in the management of these diseases PMID: 29046191
    6. Obtained results, as well as literature data, show that lower concentration of IL-31 in patients' serum may be correlated with its role in JAK/STAT signaling pathway which is involved in development of autoimmune blistering disease PMID: 28808661
    7. IL-31 gene polymorphisms were tightly associated with dilated cardiomyopathy susceptibility and contributed to worse prognosis in DCM patients. PMID: 28572699
    8. This study indicated that CXCL13 rather than IL-31 may have clinical values of diagnosis and prognosis in hepatocellular carcinoma. PMID: 27663978
    9. The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity. PMID: 28408397
    10. IL31 and its receptor, IL31RA, are highly expressed in various human and mouse cancer cell lines, as well as in tumor specimens from cancer patients. MC38 murine colon carcinoma cells depleted of IL31 exhibit an increase in invasive and migratory properties in vitro. PMID: 28147314
    11. this study shows that IL-31 may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly PMID: 28303765
    12. While serum TSLP levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31, IL-33 and sST2 were affected to a small extent. We found a positive correlation between TSLP, IL-31 and IL-33, and an inverse relationship between IL-33 and sST2 PMID: 27152943
    13. Suggest that IL-31 gene may play a role in the development of systemic lupus erythematosus. PMID: 26769434
    14. High IL31 expression is associated with Endometrial Cancer. PMID: 27340318
    15. In a CML patient with pruritus receiving imatinib mesylate, IL-31 and IL-33 serum levels were significantly higher than controls. Imatinib could cause keratinocyte injury, the release of IL-33, and the consequent interaction with its receptor on mast cells, inducing IL-31 secretion. The IL-31/IL-33 axis may be involved in the pathogenesis of skin side effects related to imatinib mesylate treatment. PMID: 26316486
    16. Distinct polymorphic variants of the IL-31 gene may be involved in the patho-genesis of mastocytosis, and IL-31 may be involved in the induction of pruritus in patients with mastocytosis. PMID: 27276346
    17. Serum/pleural fluid IL-31 levels are elevated in tuberculous pleural effusion. PMID: 26864868
    18. both SCF and IL-31 play an important role in mediating inflammation and enhancing severity of atopic asthma. PMID: 26853551
    19. IL-31 affects keratinocyte differentiation in multiple ways and the IL-1 cytokine network is a major downstream effector of IL-31 signaling in deregulating the physical skin barrier. PMID: 26944931
    20. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. PMID: 26198770
    21. The results of our analyses regarding serum levels and receptor expression do not suggest a central role of IL-31 in Mycosis fungoides/Sezary syndrome pathogenesis. PMID: 25488078
    22. In summary, TGF-beta1 and IL-31 were linked to progression from chronic hepatitis B to liver cirrhosis, and correlated well with the severity of disease. PMID: 25710085
    23. An increase of IL-31 serum levels in postmenopausal women with decreased bone mineral density, is shown. PMID: 26449657
    24. a possible systemic involvement of IL-31 and the absence of a systemic involvement of IL-33 in allergic contact dermatitis. PMID: 26357000
    25. crucial requirements for IL-31 signaling and its counter-regulation by SOCS3 PMID: 26306032
    26. IL-31 expression in allergic rhinitis aggravated and amplified Th2 inflammation as well as mucin production PMID: 25285475
    27. The IL-31 serum level was significantly higher in cutaneous T-cell lymphoma patients than in the control group but there were no positive correlation between IL-31 serum level and pruritus. PMID: 25176053
    28. IL-31 is overexpressed in the lesional skin of LP but its expression does not correlate with intensity of pruritus. PMID: 25756056
    29. IL-31 was increased after IVIG treatment in patients with KD and was significantly associated with CAL formation. PMID: 25122210
    30. Case Report: sporadic lichen amyloidosis with high expression of Il31. PMID: 24573820
    31. The results of this study suggest that the severity of atopic dermatitis in a Polish population is associated with some specific haplotypes of the IL-31 gene and renew questions concerning the role of IL-31 in pruritus in atopic dermatitis. PMID: 25534405
    32. enhanced Th2 cytokine levels was correlated with IL-31 expression in NPs and provide a possible explanation for IL-31's regulatory role in the pathogenesis of NPs. PMID: 24515918
    33. the results suggest that IL-31 may be a candidate gene associated with the pathogenesis of rheumatoid arthritis PMID: 25572240
    34. The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
    35. TARC and interleukin-31 may be biomarkers for adult atopic dermatitis PMID: 24984931
    36. IL-31 may play an important role in the pathophysiology of uremic pruritus. PMID: 25270263
    37. IL-31-positive cells were observed as mononuclear infiltrating cells and as CD11b co-expressing cells in severe atopic dermatitis samples. PMID: 24667097
    38. Data show that STAT6 and NF-kappaB are central players in mediating IL-31 expression induced by IL-4/IL-33. PMID: 24943220
    39. EGFR-TK inhibitors could cause keratinocytes injury, the release of IL-33 and the consequent interaction with its receptor on mast cells, that induces the secretion of several factors capable to cause skin manifestations, included IL-31 PMID: 23794184
    40. IL-31 seems to be another sweat stimulator. PMID: 23874436
    41. CD4+CD26- malignant cells specifically produce IL-31 and clinical resolution of pruritus correlates with decreased IL-31 levels in the circulation PMID: 23698099
    42. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. PMID: 23392388
    43. IL-31 induces pro-inflammatory effects in activated human macrophages via STAT-1 and 5 phosphorylation. Interleukin-31-induced ERK 1/2 activation contributes to the underlying mechanism of Th1 cytokine IL-12 suppression in macrophages. PMID: 23621408
    44. Il-31 is not a TH2 cytokine in the classical sense but is likely to be expressed by a number of cells in an allergic situation in which IL-4 is present and possibly contribute to the allergic reaction. PMID: 23694808
    45. hypothesize that an altered regulation of IL-31 gene expression influence clinical course of AD. The available published data and our results lend support to an important role of IL-31 gene polymorphism in AD pathogenesis PMID: 22827739
    46. IL-31-631 T>G polymorphism was significantly associated with IL-31 blood level but not with disease susceptibility. PMID: 21952721
    47. T cells in chronic atopic dermatitis (AD) skin produce IL-31 and AD lesions contain increased levels of these IL-31-producing T cells. PMID: 22621183
    48. IL-31 serum levels correlate with the SCORAD score, sleeplessness, and Th2 cytokines including IL-4 and IL-13, in sixty children with the extrinsic type of atopic dermatitis. PMID: 22509760
    49. IL-31-specific activation of dendritic cells may be part of a positive feedback loop driving the progression of inflammatory skin diseases. PMID: 22539792
    50. Distinct SPINK5 and IL-31 gene variants (SNPs) were associated with the development of atopic eczema and non-atopic hand dermatitis in Taiwanese nurses. PMID: 22017185

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
  • 数据库链接：

    HGNC: 19372

    OMIM: 609509

    KEGG: hsa:386653

    STRING: 9606.ENSP00000366234

    UniGene: Hs.569071