Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 单克隆抗体
  4. FILIP1L Monoclonal Antibody

FILIP1L Monoclonal Antibody

  • 货号：
    CSB-MA679703A0m
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: FILIP1L antibody at 1:1000
      Secondary
      Goat polyclonal to mouse IgG at 1/50000 dilution
      Predicted band size: 102 kDa
      Observed band size: 29, 80, 102, 130 KDa
      Exposure time：5min
  • 其他：

产品详情

  • 产品名称：
    Mouse anti-Homo sapiens (Human) FILIP1L Monoclonal Antibody antibody
  • Uniprot No.：
    Q4L180
  • 基因名：
    FILIP1L
  • 别名：
    130 kDa GPBP-interacting protein antibody; 90 kDa GPBP-interacting protein antibody; COL4A3BPIP antibody; DOC-1 antibody; DOC1 antibody; Downregulated in ovarian cancer 1 81 kDa isoform antibody; FIL1L_HUMAN antibody; Filamin A-interacting protein 1-like antibody; FILIP1L antibody; GIP130 antibody; GIP130a antibody; GIP130b antibody; GIP130c antibody; GIP90 antibody; GPBP interacting protein 90 antibody; Protein down-regulated in ovarian cancer 1 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Filamin A-interacting protein 1-like protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal Antibody
  • 抗体亚型：
    IgG1
  • 纯化方式：
    >95%, Protein G purified
  • 克隆号：
    4H7G5
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
  • 基因功能参考文献：
    1. FILIP1L inhibits progression in colorectal cancer by inhibiting tumor cell proliferation and angiogenesis. PMID: 27750216
    2. Studies have shown that FILIP1L expression is related with inhibition of metastases and chemoresistance of ovarian neoplasm, which is associated with downregulation of EMT through beta-catenin degradation. FILIP1L expression correlates with significantly improved overall survival. PMID: 27776341
    3. these findings suggest that FILIP1L reduces beta-catenin levels, which may lead to the transcriptional downregulation of WNT target genes such as MMPs, resulting in inhibition of metastasis PMID: 24327474
    4. down-regulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in various cancers. PMID: 24340050
    5. these findings suggest that downregulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in ovarian cancer and that modulation of FILIP1L expression has the potential to be a target for ovarian cancer therapy. PMID: 21693594
    6. a novel function for FILIP-1L and a pathway for Hsf1 degradation through the ubiquitin-proteasome system. PMID: 21784850
    7. DOC1 might play a role in mediating some of the effects of EMAP-II on endothelial cells PMID: 15935955

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Membrane. Nucleus.
  • 蛋白家族：
    FILIP1 family
  • 组织特异性：
    Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. D
  • 数据库链接：

    HGNC: 24589

    OMIM: 612993

    KEGG: hsa:11259

    STRING: 9606.ENSP00000346560

    UniGene: Hs.104672