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TUBB2A Monoclonal Antibody

  • 货号：
    CSB-MA000312
  • 规格：
    ￥660
  • 图片：
    • 1) Input: Mouse Brain Tissue Lysate 2) IP product: IP dilute 1: 200 Western blot analysis: primary antibody : 1: 10000 Secondary antibody: Goat anti-Mouse IgG, Light chain specific (S003), 1: 5000
    • Western blot analysis of 1) Mouse Brain tissue, 2) Rat Brain tissue, diluted at 1:100000.
  • 其他：

产品详情

  • Uniprot No.：
    Q13885
  • 基因名：
  • 别名：
    TUBB2A antibody; TUBB2 antibody; Tubulin beta-2A chain antibody; Tubulin beta class IIa antibody
  • 宿主：
    Mouse
  • 反应种属：
    Mouse,Rat,Human
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    M, R, (H)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能参考文献：
    1. TUBB2A missense mutation is associated with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay. PMID: 28840640
    2. study associates mutations in TUBB2A with the spectrum of "tubulinopathy" phenotypes PMID: 24702957
    3. This is the first study showing that paclitaxel neuropathy risk is influenced by polymorphisms regulating the expression of a beta-tubulin gene. PMID: 22718863
    4. Class II beta-tubulin may be very useful for immunohistochemical diagnosis of classical Hodgkin's lymphoma. PMID: 22449234
    5. Data suggest that the increased betaII- and betaIII-tubulin contributed significantly to the resistance phenotype. PMID: 22180309
    6. lack of mutations in early stage lung cancer PMID: 12209967
    7. Mutations of the beta-tubulin gene, which might be a contraindication for chemotherapy based on taxans, were very rare events in gastric cancer. PMID: 12861402

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  • 相关疾病：
    Cortical dysplasia, complex, with other brain malformations 5 (CDCBM5)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 组织特异性：
    High expression in brain, where it represents 30% of all beta-tubulins.
  • 数据库链接：

    HGNC: 12412

    OMIM: 615101

    KEGG: hsa:7280

    STRING: 9606.ENSP00000369703

    UniGene: Hs.654543