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  4. Recombinant Human Thymosin beta-4 (TMSB4X) (Active)

Recombinant Human Thymosin beta-4 (TMSB4X) (Active)

In Stock
  • 货号：
    CSB-AP000381HU
  • 规格：
    ￥2568
  • 图片：
  • 其他：

产品详情

  • 纯度：
    >97% as determined by SDS-PAGE.
  • 内毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The biological activity determined by its ability to produce a protective effect against hydrogen peroxide in primary lung fibroblasts is in a concentration range of 0.5 - 10 μg/ml.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fx; Hematopoietic system regulatory peptide; Prothymosin beta 4; PTMB 4; PTMB4; Seraspenide; T beta 4; T beta-4; TB4X; THYB 4; Thyb4; Thymosin beta 4; Thymosin beta 4 X chromosome; Thymosin beta 4 X linked; TMSB 4; TMSB4; Tmsb4x; TYB4_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.Coli
  • 分子量：
    4.9 kDa
  • 表达区域：
    2-44aa
  • 氨基酸序列
    SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA GES
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from a 0.2 µm filtered concentrated solution in 20 mM PB, pH 7.4.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.; Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
  • 基因功能参考文献：
    1. Serum Tbeta4 level can be used as a biomarker for the diagnosis of NASH and was negatively correlated with the oxidation state of the liver PMID: 29271227
    2. we suggest that overexpression of Tbeta4 might play a role in the progression of gastric gastrointestinal stromal tumors PMID: 28756979
    3. Tbeta4 exerts a protective effect on murine colitis, indicating that recombinant adeno-associated virus carrying thymosin beta4 could potentially be developed into a promising agent for the therapy of inflammatory bowel diseases. PMID: 28127198
    4. Results showed that the TMSB4 pseudogene, lncRNA-MSR, was upregulated in the damaged cartilage and was activated in chondrocytes in response to mechanical stress. Furthermore, lncRNA-MSR regulated the expression of TMSB4 by competing with miRNA-152 in chondrocytes. PMID: 27469625
    5. Tbeta4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro and decreased tumor growth in vivo. Mechanistic investigations revealed a significant decrease in Notch1 activation in Tbeta4 gene-silenced cells. PMID: 27521796
    6. Developed an innovative biotechnological method for thymosin beta4 production that employs the peptide acetylation in vivo. PMID: 27015974
    7. Serum thymosin beta4 concentrations were correlated with the occurrence and severity of obstructive sleep apnea syndrome. PMID: 27086675
    8. Overexpression of Tbeta4 enhanced cell proliferation and colony formation in oral squamous cell carcinoma. PMID: 26276576
    9. Tbeta-4 was validated in clinical samples using a tissue microarray to predict overall survival in colon cancer patients PMID: 26556858
    10. this study demonstrated, for the first time, that Tbeta4 was down-regulated in ROS-stimulated PDLCs as well as Tbeta4 activation exhibited anti-inflammatory effects and anti-osteoclastogenesis in vitro. PMID: 26789270
    11. this study demonstrates, for the first time, that Tbeta4 is expressed in developing periodontal tissue and that its expression is associated with osteoblastic/cementoblastic differentiation. PMID: 26361868
    12. This article reviews the potential role of thymosin beta 4 in liver fibrosis by describing the effects of exogenous and endogenous thymosin beta 4 , and discusses the possible signaling pathway regulated by TB4X. [review] PMID: 26006229
    13. The results of the present study suggested that Tb4 may promote HB metastasis via the induction of EMT, and that Tb4 may therefore be a target for the development of novel treatments for patients with Hepatoblastoma . PMID: 25695679
    14. these results suggest that NO could regulate the expression of Tbeta4 by direct or indirect effect of HIF-1alpha on Tbeta4 promoter. PMID: 25271630
    15. the exchange of bound actin between Tbeta4 and profilin involves both steric and allosteric components. PMID: 25313062
    16. Thymosin beta4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/beta-catenin signaling pathway. PMID: 25218472
    17. Regarding HCC, Tbeta4 reactivity was detected in 7/23 cases (30%) and Tbeta10 reactivity in 22/23 (97%) cases analyzed, adding HCC to human cancers that express these beta-thymosins. PMID: 24704991
    18. Thymosin beta-4 levels in the serum and synovial fluid of knee osteoarthritis patients are significantly correlated with disease severity. PMID: 23816466
    19. Thymosin beta 4 silencing in glioblastoma cells inhibits cell migration and invasion. PMID: 24355709
    20. cell trafficking of thymosin beta-4 PMID: 23967050
    21. Tbeta4 expression was upregulated significantly in primary and recurrent colorectal cancers PMID: 24098025
    22. Tbeta4 expression was also co-localized with CD133 expression in primary ovarian carcinomas. PMID: 23055022
    23. Detection its amino acid conservation suggest an important role of Tb4 in the homeostasis of the mammalian oral cavity. PMID: 23262355
    24. Thymosin beta4 could be associated with morphogenesis and tumor invasion in ameloblastoma and may play a role in the behavior of ameloblastoma. PMID: 23235961
    25. Tbeta4 plays a key role in odontoblastic differentiation of human dental pulp cells. PMID: 23613983
    26. Tbeta4 is an important myocardin-related transcription factor (MRTF) regulator that controls the G-actin-MRTF-A interaction.Tbeta4 competed with MRTF-A for G-actin binding, thus interfering with G-actin-MRTF-A complex formation. PMID: 23811404
    27. REVIEW: role of Tbeta4 in thrombosis and platelet aggregation PMID: 22944663
    28. Thymosin beta4 expression reveals intriguing similarities between fetal and cancer cells. PMID: 23045970
    29. investigated whether GSK-3 activity is regulated by thymosin beta-4 (Tbeta4) and associated with Tbeta4-mediated migration in gastric cancer cells; expression of GSK-3alpha, beta-catenin and E-cadherin could be negatively regulated by Tbeta4 induced ERK phosphorylation; suggests that Tbeta4 could be a novel regulator to control Wnt signal pathway PMID: 22328534
    30. The Our data confirm the concept that externally added Tbeta4 must be internalized to induce intracellular mechanisms supporting endothelial cell migration. PMID: 22652458
    31. Thymosin beta4 Tbeta4 may play an important role in bone degradation and inflammation in RA but not OA. PMID: 22004227
    32. kininogen-1 and thymosin-beta(4) are potential new biomarkers for human chronic hepatitis C. PMID: 21496200
    33. Tbeta4 is regulated by IL-18 and is involved in IL-18-enhanced IFN-gamma secretion in NK cells. PMID: 21742406
    34. Elevated expression of thymosin beta4 is associated with early-stage cervical cancers. PMID: 21213129
    35. Thymosin beta4 may play a role in diabetic retinal neovascularization. PMID: 21332672
    36. findings suggest that Tbeta4 by sequestering actin prevents binding of AKT, thus inhibiting its phosphorylation PMID: 21514425
    37. The expression of thymosin beta4 is highly related with tumorigenesis of certain tumors including the osteosarcoma and colorectal cancers. PMID: 20975530
    38. Describe beta-thymosins in bronchoalveolar lavage fluid and their possible involvement in the pathogenesis of scleroderma lung disease. PMID: 21314931
    39. we have identified an extracellular signaling pathway where Tbeta4 increases cell surface ATP levels via ATP synthase and have shown further that ATP-responsive P2X4 receptor is required for Tbeta4-induced cell migration PMID: 21106936
    40. overexpression of Tbeta4 is strongly associated with HIF-1alpha and HIF-2alpha expression and is also clinicopathologically involved with lymph node metastatic potential of breast cancer PMID: 21109953
    41. The TB4 could be a hypoxia responsive regulator to control tumor cell migration in angiogenesis and tumor metastasis. PMID: 20821256
    42. colorectal cancer stem cells from different patients have higher Tbeta4 levels than normal epithelial cells PMID: 20566622
    43. Data in colon cancer tissue microarray showed that thymosin beta4 and HIF-1alpha co-localized in these biopsies. PMID: 20691219
    44. Data show a strong expression of Tbeta(4) in gut and endocrine pancreas during development. PMID: 20161756
    45. study demonstrated a clear relationship between reductions in serum thymosin beta4 level and severity of hepatitis B virus-related liver failure PMID: 20128033
    46. Data show that thymosin beta4 was differentially expressed in HGF-treated HUVECs compared with control. PMID: 12163032
    47. araC regulates the transcriptional level of thymosin beta4 and actin PMID: 12962156
    48. in response to T beta 4 stimulation, AP-1 activity increases to enhance PAI-1 transcription through its unique AP-1-like element at -59 to -52 in the PAI-1 promoter. PMID: 14592829
    49. upregulation of Tbeta-4, by promoting the disruption of cell-cell adhesion and consequential activation of the beta-catenin signaling, could be event in the acquisition of growth advantages as well as invasive phenotypes in human colorectal carcinomas PMID: 15235586
    50. activated factor XIII incorporates thymosin beta(4) into the isolated gamma-module and alphaC-domain (fibrinogen A alpha); in fibrin the latter serves as the major incorporation site PMID: 15311936

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Thymosin beta family
  • 组织特异性：
    Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.
  • 数据库链接：

    HGNC: 11881

    OMIM: 300159

    KEGG: hsa:7114

    STRING: 9606.ENSP00000370007

    UniGene: Hs.437277