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  4. Recombinant Rat Cardiotrophin-1 protein (Ctf1)

Recombinant Rat Cardiotrophin-1 protein (Ctf1)

In Stock
  • 货号：
    CSB-AP000211RA
  • 规格：
    ￥2124
  • 图片：
  • 其他：

产品详情

  • 纯度：
    >95% as determined by SDS-PAGE.
  • 内毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x106 IU/mg.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ctf1Cardiotrophin-1; CT-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length
  • 来源：
    E.Coli
  • 分子量：
    21.4 kDa
  • 表达区域：
    1-203aa
  • 氨基酸序列
    MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP VPEPVATSAL FTSNSAAGVF SAKVLGLHVC GLYGEWVSRT EGDLGQLVPG GVA
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    0.2 μm filtered 20 mM PB, pH 7.4, 150mM NaCl ,lyophilized
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
  • 基因功能参考文献：
    1. Cardiotrophin-1 modulates glucose transport in cardiomyocytes positively or negatively depending on its concentration. PMID: 23277190
    2. Cardiomyocytes treated with CT-1 present high spontaneous Ca(2+) release during diastole, a mechanism linked to arrhythmogenicity in the pathologic heart. PMID: 22787135
    3. Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction. PMID: 22733458
    4. Data suggest a key role for CT-1 in cardiac remodeling induced by aldosterone independent of changes in blood pressure levels. PMID: 21926338
    5. CT-1 induces VSMCs proliferation, hypertrophy and extracellular matrix production, and is upregulated in hypertension and by aldosterone. CT-1 may represent a new target of vascular wall remodeling in hypertension PMID: 20216087
    6. Cardiotrophin-1 promotes the outgrowth of embryonic cranial motor neurons in isolated stage E12 hindbrain explants. PMID: 11932952
    7. CT1 has a role in hypertrophy of rat cardiomyocytes as measured by an increase in cell area and enhanced protein: DNA ratio PMID: 12027405
    8. Ctf1 has a possible role in post-MI wound healing PMID: 14674704
    9. hypertrophic responses to cardiotrophin-1 is mitogen activated protein kinase kinase 5-mitogen-activated protein kinase 7 pathway PMID: 15623435
    10. Motoneurons retrogradely transport from the tongue radiolabeled GDNF, BDNF, and cardiotrophin-1; cardiotrophin-1 follows a strict degradation pathway after retrograde transport to the soma. PMID: 15659589
    11. CT-1 can affect the expression of GATA4 mRNA and the binding activity of cardiac myocytes PMID: 19327894
    12. CT-1 signals through p38, ERK, and Akt in a parallel manner to activate NF-kappa B and that NF-kappa B is required for CT-1 to mediate its full cytoprotective effects in cardiac myocytes. PMID: 11448959

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-6 superfamily
  • 组织特异性：
    Expressed in the ventricle and atrium of adult rats. Also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Not detected in brain, colon, testis, spleen or thymus. Overexpressed in the ventricles in the case of hypertensio
  • 数据库链接：

    KEGG: rno:29201

    STRING: 10116.ENSRNOP00000025646

    UniGene: Rn.10253