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AADAT Antibody

  • 货号：
    CSB-PA843276LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA843276LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA843276LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AADAT Polyclonal antibody
  • Uniprot No.：
    Q8N5Z0
  • 基因名：
    AADAT
  • 别名：
    2 aminoadipate aminotransferase antibody; 2 aminoadipate transaminase antibody; 2-aminoadipate aminotransferase antibody; 2-aminoadipate transaminase antibody; Aadat antibody; AADAT_HUMAN antibody; Aadt antibody; AI875679 antibody; Alpha aminoadipate aminotransferase antibody; Alpha-aminoadipate aminotransferase antibody; Aminoadipate aminotransferase antibody; EC 2.6.1.39 antibody; EC 2.6.1.7 antibody; KAT/AadAT antibody; KAT2 antibody; KATII antibody; Kynurenine oxoglutarate transaminase 2 antibody; Kynurenine aminotransferase II antibody; Kynurenine oxoglutarate aminotransferase II antibody; Kynurenine oxoglutarate transaminase II antibody; Kynurenine--oxoglutarate aminotransferase II antibody; Kynurenine--oxoglutarate transaminase II antibody; Kynurenine/alpha-aminoadipate aminotransferase mitochondrial [Precursor] antibody; Kynurenine/alpha-aminoadipate aminotransferase; mitochondrial antibody; L kynurenine/alpha aminoadipate aminotransferase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial protein (30-425AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AADAT Antibody (CSB-PA843276LA01HU)，的标记方式是Non-conjugated。对于AADAT Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA843276LB01HU AADAT Antibody, HRP conjugated ELISA
    FITC CSB-PA843276LC01HU AADAT Antibody, FITC conjugated
    Biotin CSB-PA843276LD01HU AADAT Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
  • 基因功能参考文献：
    1. Immunohistochemical analysis revealed the presence of KAT I, II, and III in all examined corneal sections. PMID: 28706436
    2. he optimised method of protein production provides a fast and reliable technique to generate large quantities of active human KAT2 suitable for future small-molecule lead compound screening and structural design work. PMID: 26773745
    3. Participants with major depression had lower levels of kynurenine compared to controls, with intermediate concentrations in somatoform patients. PMID: 24140252
    4. Somatization is characterized by disorders in kynurenine aminotransferase activity and an increased neurotoxic potential PMID: 21712776
    5. association of SNP AADAT+401C/T with the host immune response to bacterial meningitis, suggesting that this SNP may affect the host ability in recruitment of leukocytes to the infection site PMID: 21473761
    6. analysis of the crystal structure of kynurenine aminotransferase II PMID: 18056995
    7. analysis of the crystal structure of human kynurenine aminotransferase II PMID: 18056996
    8. A human cDNA encodes a 425-residue protein with a mitochondrial cleavage signal and a pyridoxal-phosphate binding site, ~70% identical to the mouse and rat AADAT orthologs. Bacterial expression studies confirm that the gene encodes AADAT activity. PMID: 12126930

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class-I pyridoxal-phosphate-dependent aminotransferase family
  • 组织特异性：
    Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.
  • 数据库链接：

    HGNC: 17929

    OMIM: 611754

    KEGG: hsa:51166

    STRING: 9606.ENSP00000226840

    UniGene: Hs.529735