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ABCA8 Antibody

  • 货号：
    CSB-PA000781
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using ABCA8 Polyclonal Antibody
    • Western Blot analysis of HuvEc PC12 cells using ABCA8 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O94911
  • 基因名：
    ABCA8
  • 别名：
    ABCA8 antibody; KIAA0822ATP-binding cassette sub-family A member 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ABCA8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes.; Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels.
  • 基因功能参考文献：
    1. ABCA8 facilitates cholesterol efflux and modulates HDL-cholesterol levels. PMID: 28882873
    2. Genes ABCC7, A3, A8, A12, and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels PMID: 28468577
    3. These data suggest a direct relationship between the levels of ABCA8 and the ectopic expression of alpha-syn and increased expression of p25alpha PMID: 23948991
    4. ABCA8 is highly expressed in human brain and regulates lipid metabolism in oligodendrocytes, potentially playing a role in myelin formation and maintenance. PMID: 23560799
    5. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
    6. Functional analysis of the transport properties of ABCA8. PMID: 12379217

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 组织特异性：
    Widely expressed with higher expression in heart, skeletal muscle and liver. Highly expressed in the superior frontal white matter and inferior temporal white matter.
  • 数据库链接：

    HGNC: 38

    OMIM: 612505

    KEGG: hsa:10351

    STRING: 9606.ENSP00000269080

    UniGene: Hs.58351