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ABR Antibody

  • 货号：
    CSB-PA622521LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: ABR antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 98, 94, 36, 93 kDa
      Observed band size: 98 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA622521LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ABR Polyclonal antibody
  • Uniprot No.：
    Q12979
  • 基因名：
    ABR
  • 别名：
    abr antibody; ABR_HUMAN antibody; Active BCR related antibody; Active BCR related gene antibody; Active breakpoint cluster region related protein antibody; Active breakpoint cluster region-related protein antibody; MDB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Active breakpoint cluster region-related protein (797-859AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ABR Antibody (CSB-PA622521LA01HU)，的标记方式是Non-conjugated。对于ABR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA622521LB01HU ABR Antibody, HRP conjugated ELISA
    FITC CSB-PA622521LC01HU ABR Antibody, FITC conjugated
    Biotin CSB-PA622521LD01HU ABR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity.
  • 基因功能参考文献：
    1. ABR depletion leads to G2/M accumulation in human embryonic stem cells. Centrosome dynamics and mitotic fidelity are compromised upon ABR depletion. When mitosis progresses without ABR, human embryonic stem cells show a high incidence of aneuploidy. PMID: 28579391
    2. During vestibular morphogenesis, Abr and Bcr play complementary roles. Small Rho-related GTPases like Abr and Bcr are important for balance and motor coordination. PMID: 11921339
  • 亚细胞定位：
    Cell projection, dendritic spine. Cell projection, axon. Cell junction, synapse.
  • 组织特异性：
    Highly enriched in the brain. Much weaker expression in heart, lung and muscle.
  • 数据库链接：

    HGNC: 81

    OMIM: 600365

    KEGG: hsa:29

    STRING: 9606.ENSP00000303909

    UniGene: Hs.159306