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ACAT1 Antibody

  • 货号：
    CSB-PA001134GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P24752
  • 基因名：
    ACAT1
  • 别名：
    ACAT 1 antibody; ACAT antibody; acat1 antibody; Acetoacetyl CoA thiolase antibody; acetoacetyl Coenzyme A thiolase antibody; Acetoacetyl-CoA thiolase antibody; Acetyl CoA acetyltransferase; mitochondrial antibody; Acetyl Coenzyme A acetyltransferase 1 antibody; Acetyl-CoA acetyltransferase antibody; acetyl-coa acetyltransferase precursor; mitochondrial antibody; Acetyl-CoA thiolase; mitochondrial antibody; acetyl-Coenzyme A acetyltransferase 1 antibody; MAT antibody; mitochondrial acetoacetyl-CoA thiolase antibody; mitochondrial antibody; RATACAL antibody; T2 antibody; testicular tissue protein Li 198 antibody; THIL antibody; THIL_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ACAT1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.
  • 基因功能参考文献：
    1. High ACAT1 expression is associated with breast cancer. PMID: 30092298
    2. Insulin promotes progression of colon cancer by upregulation of ACAT1. PMID: 29793481
    3. ACAT1 exonic mutations that affect ESE sequences may result in aberrant splicing. This may affect the activity of mitochondrial acetoacetyl-CoA thiolase. PMID: 27748876
    4. compound heterozygous of ACAT1 gene mutations probably underlie the beta-ketothiolase deficiency in our patient PMID: 27264805
    5. Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms. PMID: 25639359
    6. the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
    7. these findings indicate that ACAT1 expression could serve as a potential prognostic marker in prostate cancer, specifically in differentiating indolent and aggressive forms of cancer. PMID: 24311408
    8. ACAT1 expression is substantially elevated in human castration-resistant metastatic prostate cancer tissues. PMID: 23443136
    9. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
    10. We herein identified a common mutation, R208X, in Vietnamese patients. We identified R208X homozygously in six patients and heterozygously in two patients among eight Vietnamese patients. PMID: 20156697
    11. the siblings with the same T2 gene mutations present different clinical severity of T2 deficiency PMID: 20046049
    12. Single base substitutions at the initiator codon produced wild-type T2 polypeptide to various degrees PMID: 12754704
    13. mild mutations (A132G, D339-V340insD) retained some residual T2 activity PMID: 15128923
    14. Cloning and sequencing long range PCR products revealed a 6.4kb deletion. Alu element-mediated unequal homologous recombination between an Alu-Sx in intron 1 and another Alu-Y in intron 4 appears to be responsible for this deletion. PMID: 16935016
    15. E252del is a temperature-sensitive K(m) mutant. PMID: 17236799
    16. Crystallographic and kinetic studies were made on mitochondrial acetyl-CoA thiolase: the importance of potassium and chloride ions were noted for its structure and function. PMID: 17371050
    17. A point mutation was responsible for the aberrant RNA splicing of the mitochondrial acetoacetyl-CoA thiolase gene. PMID: 18511318
    18. sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not PMID: 18562306
    19. I/D polymorphism of ACE gene and AC AT1 gene influence the development of hypertension and Left Ventricular Hypertrophy in Hemodialysis patients. PMID: 19112833

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  • 相关疾病：
    3-ketothiolase deficiency (3KTD)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Thiolase family
  • 数据库链接：

    HGNC: 93

    OMIM: 203750

    KEGG: hsa:38

    STRING: 9606.ENSP00000265838

    UniGene: Hs.232375