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  4. ACOT13 Antibody

ACOT13 Antibody

  • 中文名称：
    ACOT13兔多克隆抗体
  • 货号：
    CSB-PA023493GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NPJ3
  • 基因名：
    ACOT13
  • 别名：
    15 Kd protein antibody; ACO13_HUMAN antibody; Acot13 antibody; Acyl-CoA thioesterase 13 antibody; Acyl-coenzyme A thioesterase 13 antibody; HT012 antibody; hypothalamus protein HT012 antibody; MGC4961 antibody; PNAS 27 antibody; PNAS27 antibody; Thioesterase superfamily member 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human THEM2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
  • 基因功能参考文献：
    1. Markers in DYX2 genes KIAA0319 and FAM65B were associated with cortical thickness in the left developing orbitofrontal region and global fractional anisotropy, respectively. KIAA0319 and ACOT13 were suggestively associated with overall fractional anisotropy and left pars opercularis cortical thickness, respectively. PMID: 25953057
    2. This study models the reaction of the hTHEM2 enzyme by first-principles methods to elucidate atomic and electronic details of the mechanism, its transition-state (TS) conformation, and the free-energy landscape of the process. PMID: 24894958
    3. study failed to show any association of THEM2 SNPs with developmental dyslexia in an Indian population. PMID: 23954868
    4. The results of this study confirmed that both FOXP2 and KIAA0319/TTRAP/THEM2 genes play an important role in human language development, but probably through different cerebral pathways. PMID: 22262880
    5. analysis of human thioesterase superfamily member 2 crystal structure PMID: 16934754
    6. Small interference RNA silencing in cell line HCT116 shows that the hthem2 gene is essential for the cell sustained proliferation. PMID: 17045243
    7. Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2) and the homeodomain transcription factor Pax3 (paired box gene 3), respectively, as PC-TP-interacting proteins. PMID: 17704541
    8. The physiological role of hTHEM2 involves catalysis of the hydrolysis of cytosolic medium-to-long-chain acyl-CoA thioesters. PMID: 19170545

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  • 亚细胞定位：
    Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    Thioesterase PaaI family
  • 数据库链接：

    HGNC: 20999

    OMIM: 615652

    KEGG: hsa:55856

    STRING: 9606.ENSP00000230048

    UniGene: Hs.731605