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ACR Antibody

  • 货号：
    CSB-PA000002
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using Acrosin Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P10323
  • 基因名：
    ACR
  • 别名：
    Acr antibody; ACRO_HUMAN antibody; Acrosin heavy chain antibody; Acrosin precursor antibody; ACRS antibody; Preproacrosin antibody; Proacrosin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Acrosin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
  • 基因功能参考文献：
    1. Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively. PMID: 23675907
    2. Sperm DNA damage is closely related with sperm-nucleoprotein transition, acrosin activity and seminal parameters. PMID: 23297503
    3. DNA immunization against proacrosin impairs fertility in male mice. PMID: 22452365
    4. Binding sites for recombinant human zona pellucida (ZP) glycoproteins located at the N- and C-termini of proacrosin reveal a key role of the proenzyme in the interaction. PMID: 15950651
  • 蛋白家族：
    Peptidase S1 family
  • 数据库链接：

    HGNC: 126

    OMIM: 102480

    KEGG: hsa:49

    STRING: 9606.ENSP00000216139

    UniGene: Hs.370870