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ACTR8 Antibody

  • 货号：
    CSB-PA872523LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ACTR8 antibody at 16µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: HCT116 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 71, 59, 37 kDa
      Observed band size: 71 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ACTR8 Polyclonal antibody
  • Uniprot No.：
    Q9H981
  • 基因名：
    ACTR8
  • 别名：
    Actin-related protein 8 antibody; Actr8 antibody; ARP8_HUMAN antibody; hArp8 antibody; INO80 complex subunit N antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Actin-related protein 8 protein (35-175AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ACTR8 Antibody (CSB-PA872523LA01HU)，的标记方式是Non-conjugated。对于ACTR8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872523LB01HU ACTR8 Antibody, HRP conjugated ELISA
    FITC CSB-PA872523LC01HU ACTR8 Antibody, FITC conjugated
    Biotin CSB-PA872523LD01HU ACTR8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
  • 基因功能参考文献：
    1. Plays a regulatory role in the binding of Arp8 to DNA. PMID: 25299602
    2. Binding studies reveal that Arp8 and the Arp8-Arp4-actin-HSA sub-complex of INO80 strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting that Arp8 functions as a nucleosome recognition module. PMID: 22977180
    3. These results suggest that ARP8 is required for the recruitment of the mammalian INO80 complex to the laser-induced DNA damage sites. PMID: 20971067
    4. Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. PMID: 18163988
  • 亚细胞定位：
    Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes.
  • 蛋白家族：
    Actin family, ARP8 subfamily
  • 数据库链接：

    HGNC: 14672

    KEGG: hsa:93973

    STRING: 9606.ENSP00000336842

    UniGene: Hs.412186