ACTRT1 Antibody
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货号:CSB-PA167754
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:Q8TDG2
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基因名:ACTRT1
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别名:ACTRT1 antibody; ARPT1 antibody; HSD27Actin-related protein T1 antibody; ARP-T1 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Fusion protein of Human ACTRT1
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,WB
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推荐稀释比:
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
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基因功能参考文献:
- Study identified mutations in the ACTRT1 gene, which encodes actin-related protein T1 (ARP-T1), in two of the six families with Bazex-Dupre-Christol syndrome (BDCS) that were examined in this study. ARP-T1 was found to directly bind to the GLI1 promoter, thus inhibiting GLI1 expression, and loss of ARP-T1 led to activation of the Hedgehog pathway in individuals with BDCS. PMID: 28869610
- Describes the discovery of two actin-related proteins as major components in a cytoskeletal, nonmotile structure of bull spermatozoa, suggesting that certain members of this family of proteins may serve functions other than nucleation of actin filaments. PMID: 12243744
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亚细胞定位:Cytoplasm, cytoskeleton. Cytoplasm. Nucleus.
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蛋白家族:Actin family
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组织特异性:In skin, expressed in the basal, spinous and granular layers of the epidermis. Also expressed in hair follicles, sebaceaous glands, eccrine sweat glands and semen.
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数据库链接:
HGNC: 24027
OMIM: 300487
KEGG: hsa:139741
STRING: 9606.ENSP00000360165
UniGene: Hs.680125
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