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ACVR1C Antibody

  • 货号：
    CSB-PA961708
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA961708(ACVR1C Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA961708(ACVR1C Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8NER5
  • 基因名：
  • 别名：
    Activin A receptor; type IC antibody; Activin receptor like kinase 7 antibody; Activin receptor type 1C precursor antibody; Activin receptor type IC antibody; Activin receptor type-1C antibody; Activin receptor-like kinase 7 antibody; ACTR IC antibody; ACTR-IC antibody; ACTRIC antibody; ACV1C_HUMAN antibody; Acvr1c antibody; ACVRLK7 antibody; ALK 7 antibody; ALK-7 antibody; ALK7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ACVR1C
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • 基因功能参考文献：
    1. reduced expression in sensitive skin; plays crucial roles in the pathogenesis of sensitive skin PMID: 26836979
    2. Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma. PMID: 26406402
    3. Alk7 is expressed in male germ cells and Sertoli cells. PMID: 26289399
    4. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer. PMID: 23793810
    5. Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients. PMID: 23765385
    6. reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression. PMID: 22086737
    7. These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. PMID: 21356369
    8. cDNA cloning, expression studies and chromosome mapping PMID: 12063393
    9. ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated PMID: 12606401
    10. ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components PMID: 15107418
    11. the Nodal-ALK7 pathway inhibits cell proliferation by inducing G(1) cell cycle arrest PMID: 15150278
    12. AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. PMID: 15196700
    13. ALK7-induced apoptosis is at least in part through two Smad-dependent pathways, Bax/Bcl-2 and Xiap. PMID: 16603637
    14. GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID: 18480259
    15. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. PMID: 18784254
    16. One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3. PMID: 18951876
    17. Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific. PMID: 19275893

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 组织特异性：
    Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
  • 数据库链接：

    HGNC: 18123

    OMIM: 608981

    KEGG: hsa:130399

    STRING: 9606.ENSP00000243349

    UniGene: Hs.562901