ACVR2B Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) ACVR2B Polyclonal antibody
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Uniprot No.:Q13705
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基因名:
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别名:Activin A receptor type IIB antibody; Activin receptor type 2B antibody; Activin receptor type IIB antibody; Activin receptor type-2B antibody; ActR IIB antibody; ACTR-IIB antibody; ActRIIB antibody; ACVR 2B antibody; ACVR2B antibody; AVR2B_HUMAN antibody; HTX4 antibody; MGC116908 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Activin receptor type-2B protein (19-140AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or a...显示更多
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基因功能参考文献:
- the A allele of genetic variant rs2276541 in ACVR2B is associated with lean muscle mass PMID: 26848890
- ActR-IIB is expressed in male germ cells and Sertoli cells. PMID: 26289399
- We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19. PMID: 25051287
- miR-21 interacts directly with the 3'-untranslated region of ACVR2B mRNA. Mechanical stretch suppressed ACVR2B protein levels in periodontal ligament stem cells. Gain- and loss of function of ACVR2B mediated the osteogenic differentiation of PDLSCs. PMID: 25203845
- Activin type IIB receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain. PMID: 22296042
- After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed lower levels of ActRIIb while postmenopausal women using HT showed a heightened response. PMID: 22395277
- The interaction between all five miRNAs and ACVR2B was verified by an in vitro assay. PMID: 22431721
- Mutations in Activin A Receptor Type IIB were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies. PMID: 21864452
- discussion of crystal structure of kinase domain of ActRIIB; structural analysis may be of help in developing selective inhibitors [REVIEW] PMID: 21353874
- Inhibition of negative regulators of skeletal muscle by a soluble form of activin type IIB receptor (ACE-031) increases muscle mass independent of fiber-type expression. PMID: 20466801
- analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation PMID: 12782414
- activin signaling via type II receptors requires a specific sequence for ALK4 binding PMID: 15123686
- These results indicate that haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength, although these data indicate sex-specific relationships. PMID: 17347381
- The high-resolution structure of human ActRIIB kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. PMID: 17893364
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相关疾病:Heterotaxy, visceral, 4, autosomal (HTX4)
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亚细胞定位:Cell membrane; Single-pass type I membrane protein.
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蛋白家族:Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
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数据库链接:
HGNC: 174
OMIM: 602730
KEGG: hsa:93
STRING: 9606.ENSP00000340361
UniGene: Hs.174273