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  4. ACYP2 Antibody

ACYP2 Antibody

  • 货号：
    CSB-PA080064
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P14621
  • 基因名：
    ACYP2
  • 别名：
    Acylphosphatase 2 antibody; Acylphosphatase 2 muscle type antibody; Acylphosphatase antibody; Acylphosphatase muscle type isozyme antibody; Acylphosphatase-2 antibody; Acylphosphatase2 antibody; Acylphosphate phosphohydrolase 2 antibody; Acylphosphate phosphohydrolase antibody; ACYM antibody; ACYP 2 antibody; ACYP antibody; Acyp2 antibody; ACYP2_HUMAN antibody; Muscle type acylphosphatase 2 antibody; muscle type isozyme antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ACYP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Its physiological role is not yet clear.
  • 基因功能参考文献：
    1. the genetic polymorphisms of ACYP2 and TSPYL6 are associated with increased risk of developing ischemic stroke PMID: 27686078
    2. Results found an association between the ACYP2 rs1872328 polymorphism and cisplatin-induced ototoxicity. PMID: 28445188
    3. Our results indicate that ACYP2 polymorphisms may influence the GC risk and may serve as a new precursory biomarker in the northwest Chinese Han population. PMID: 28415712
    4. Findings indicate significant associations between single nucleotide oolymorphism (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. PMID: 27894080
    5. ACYP2 gene may be associated with an increased risk of esophageal carcinoma in Chinese Han populations. Future studies to address the biological function of this polymorphism in the development of esophageal carcinoma are warranted. PMID: 28424424
    6. three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population. PMID: 27974682
    7. Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population. PMID: 28039478
    8. Data show that the acylphosphatase 2 (ACYP2) gene polymorphism significantly decreased the risk of high altitude pulmonary edema (HAPE). PMID: 27552709
    9. Rs6713088, rs843752, and rs17045754 associated with high-altitude pulmonary edema risk PMID: 28353602
    10. Results shown that the previously reported association of an ACYP2 variant with cisplatin-induced hearing loss in pediatric brain tumor patients could be replicated in an independent cohort of patients with osteosarcoma. Therefor, the ACYP2 variant should be considered a predictor of cisplatin-induced hearing loss in patients with osteosarcoma or other solid tumors PMID: 26928270
    11. These findings suggest a minor role of the single nucleotide polymorphisms of ACYP2 investigated as genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity. PMID: 25858589
    12. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. PMID: 25665007
    13. Enhanced stability is observed upon modifications of a loop region in the enzyme acylphosphatase and is achieved despite significant enthalpy losses. PMID: 23754389
    14. The study used a stopped-flow device coupled to turbidometry detection to monitor the rapid conversion of human muscle acylphosphatase into oligomers with varying heparan sulfate and protein concentrations. PMID: 22522822
    15. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. PMID: 10542090
    16. effects of 40 single point mutations on the conversion of the denatured form of the alpha/beta protein acylphosphatase (AcP) into insoluble aggregates PMID: 11799398
    17. studies of aggregates formed from human muscle acylphosphatase and disaggregation suggests that amyloid formation occurs in discrete steps whose reversibility is increasingly difficult, and dependent on the size of the aggregates PMID: 15670608
    18. Most of the conserved glycine residues in this protein could have been maintained during evolution because of their ability to inhibit amyloid aggregation. PMID: 16084386
    19. extensive mutational analysis of aggregation and disaggregation of amyloid-like protofibrils of muscle acylphosphatase PMID: 18809411

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  • 蛋白家族：
    Acylphosphatase family
  • 数据库链接：

    HGNC: 180

    OMIM: 102595

    KEGG: hsa:98

    STRING: 9606.ENSP00000378161

    UniGene: Hs.516173