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ADAM23 Antibody

  • 货号：
    CSB-PA001285LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: ADAM23 antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 92, 93 kDa
      Observed band size: 92 kDa
    • IHC image of CSB-PA001285LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA001285LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of 293 cells with CSB-PA001285LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADAM23 Polyclonal antibody
  • Uniprot No.：
    O75077
  • 基因名：
    ADAM23
  • 别名：
    ADAM23; MDC3; Disintegrin and metalloproteinase domain-containing protein 23; ADAM 23; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3; MDC-3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23 protein (498-647AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ADAM23 Antibody (CSB-PA001285LA01HU)，的标记方式是Non-conjugated。对于ADAM23 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001285LB01HU ADAM23 Antibody, HRP conjugated ELISA
    FITC CSB-PA001285LC01HU ADAM23 Antibody, FITC conjugated
    Biotin CSB-PA001285LD01HU ADAM23 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
  • 基因功能参考文献：
    1. The relationships between the decreased methylation levels of the SNAI2 and ADAM23 genes and cancer de-differentiation and haematogenous dissemination, respectively, indicate novel functions of those genes in the invasive processes. PMID: 30189837
    2. Our results demonstrate that ADAM23 expression is likely involved in the progression of epithelial ovarian cancer PMID: 29921495
    3. ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during human neural progenitor cells differentiation. PMID: 28828010
    4. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy PMID: 27760137
    5. Our data provide evidence that ADAM23 plays a role in suppression of cancer cell progression through interaction with aVb3 integrin, and suggest that downregulation of ADAM23 in SP cells may contribute toward providing a cancer stem cell phenotype PMID: 26800504
    6. High ADAM23 gene methylation is associated with gastric tumor aggressiveness. PMID: 25740824
    7. quantification of CXCL12 and ADAM23 methylation could be useful for the prediction of advanced stage of BC PMID: 25620615
    8. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
    9. The expression level of ADAM23 is likely to be involved in the progression of non-small-cell lung carcinoma, and its downregulation is probably correlated with promoter methylation. PMID: 21429053
    10. a SP1 binding site (-202/-190) that binds SP1 at the proximal promoter of human ADAM23 gene was indentified. PMID: 20851106
    11. Together, these results indicate that ADAM23 down-regulation by methylation in brain tumors is a rare event and it may help explain why brain tumor metastases are rarely found elsewhere in the body. PMID: 15862898
    12. ADAM23 is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter methylation. PMID: 16103878
    13. ADAM23 may be down-regulated by aberrant promoter hypermethylation during the progression of colorectal cancer. PMID: 19089928
    14. PrP(C) is a novel molecular partner for ADAM23 in the nervous systems. PMID: 19477226
    15. Functional role of ADAM23 during lung caner metastatic progression by negatively modulating alpha(v)beta(3) integrin activation. PMID: 19549921

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform Gamma]: Secreted.
  • 组织特异性：
    Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
  • 数据库链接：

    HGNC: 202

    OMIM: 603710

    KEGG: hsa:8745

    STRING: 9606.ENSP00000264377

    UniGene: Hs.370287