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ADAMTS10 Antibody

  • 货号：
    CSB-PA798156
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA798156(ADAMTS10 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA798156(ADAMTS10 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9H324
  • 基因名：
    ADAMTS10
  • 别名：
    A disintegrin and metalloproteinase with thrombospondin motifs 10 antibody; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif; 10 antibody; A disintegrin-like and metallopeptidase with thrombospondin type 1 motif; 10 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 10 antibody; ADAM TS10 antibody; ADAM-TS 10 antibody; ADAM-TS10 antibody; ADAMTS-10 antibody; Adamts10 antibody; ATS10_HUMAN antibody; EC 3.4.24 antibody; WMS antibody; WMS1 antibody; zinc metalloendopeptidase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ADAMTS10
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
  • 基因功能参考文献：
    1. Using siRNA, over-expression and mutagenesis, it was found ADAMTS6 inhibits and ADAMTS10 is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition. PMID: 27779234
    2. These findings support the Gly661Arg mutation of ADAMTS10 as the likely cause of POAG in beagles. PMID: 23422823
    3. ADAMTS10 participates in microfibril biogenesis rather than in fibrillin-1 turnover PMID: 21402694
    4. ADAMTS10 is a functional metalloprotease as demonstrated by cleavage of alpha2-macroglobulin PMID: 15355968
    5. Expression in human colonic cell lines. PMID: 15358598
    6. ADAMTS10 plays a major role in growth and in skin, lens, and heart development in humans. PMID: 15368195
    7. infer that folding of the complex C-terminal ancillary domain is the rate-limiting step in biosynthesis of ADAMTS10, and that it (but not catalytic domain) is sensitive to subtle changes in efficiency of signal peptide cleavage. PMID: 18567016
    8. Mutations in ADAMTS10 gene is not responsible for microspherophakia. PMID: 19696795
    9. Homozygous mutation in ADAMTS10 causes lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. PMID: 19836009

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  • 相关疾病：
    Weill-Marchesani syndrome 1 (WMS1)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 组织特异性：
    Widely expressed in adult tissues.
  • 数据库链接：

    HGNC: 13201

    OMIM: 277600

    KEGG: hsa:81794

    STRING: 9606.ENSP00000270328

    UniGene: Hs.657508