ADAMTS15 Antibody
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货号:CSB-PA582168
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规格:¥1100
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图片:
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The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA582168(ADAMTS15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA582168(ADAMTS15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
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其他:
产品详情
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Uniprot No.:Q8TE58
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基因名:ADAMTS15
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别名:A disintegrin and metalloproteinase with thrombospondin motifs 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 preproprotein antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 preproprotein antibody; ADAM metallopeptidase with thrombospondin type 1 motif 15 antibody; ADAM TS 15 antibody; ADAM TS15 antibody; ADAM-TS 15 antibody; ADAM-TS15 antibody; ADAMTS 15 antibody; ADAMTS-15 antibody; ADAMTS15 antibody; ATS15_HUMAN antibody; MGC126403 antibody
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宿主:Rabbit
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反应种属:Human,Mouse
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免疫原:Fusion protein of Human ADAMTS15
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:2000-1:10000 IHC 1:100-1:300 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
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基因功能参考文献:
- ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas. PMID: 28323982
- ADAMTS15 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
- ADAMTS15 is a candidate gene for intracranial aneurysms PMID: 25649796
- ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4. PMID: 25099234
- Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation. PMID: 23233679
- ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene PMID: 20590445
- ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma PMID: 16152618
- ADAMTS15 may be target of inactivating mutations in human cancer. PMID: 19458070
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亚细胞定位:Secreted, extracellular space, extracellular matrix. Cell surface.
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组织特异性:Expressed in fetal liver and kidney, but not in any of the adult tissues examined.
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数据库链接:
HGNC: 16305
OMIM: 607509
KEGG: hsa:170689
STRING: 9606.ENSP00000299164
UniGene: Hs.534221
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