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ADAMTS17 Antibody

  • 货号：
    CSB-PA007786
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8TE56
  • 基因名：
    ADAMTS17
  • 别名：
    A disintegrin and metalloproteinase with thrombospondin motifs 17 antibody; A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif; 17 antibody; ADAM metallopeptidase with thrombospondin type 1 motif; 17 antibody; ADAM-TS 17 antibody; ADAM-TS17 antibody; ADAMTS 17 antibody; ADAMTS-17 antibody; ADAMTS17 antibody; ATS17_HUMAN antibody; EC 3.4.24. antibody; FLJ16363 antibody; FLJ32769 antibody; OTTHUMP00000194818 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ADAMTS-17.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Secretion of ADAMTS17 requires O-fucosylation. ADAMTS17 binds fibrillin-2 but not fibrillin-1 and does not cleave either. ADAMTS17 regulates fibrillin isoform composition of microfibrils in the eye. PMID: 28176809
    2. higher Adamts17 expression is found in several human cancer cell subtypes, especially in breast ductal carcinoma and there is an inverse correlation between higher Adamts17 expression and patients' survival. PMID: 24906090
    3. The mutation in the Weill-Marchesani syndrome (WMS)- gene ADAMTS17 also causes WMS in an Indian family. PMID: 24940034
    4. A mutation in WMS-like gene ADAMTS17 also causes WMS. PMID: 24940034
    5. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. PMID: 23661674
    6. Recessive ADAMTS17 mutations are a recurrent cause of isolated spherophakia with short stature. PMID: 22486325
    7. ADAMTS17 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    8. Homozygous mutation in ADAMTS17 causes lenticular myopia, ectopia lentis, glaucoma, spheropakia, and short stature. PMID: 19836009

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  • 相关疾病：
    Weill-Marchesani-like syndrome (WMSL)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle
  • 数据库链接：

    HGNC: 17109

    OMIM: 607511

    KEGG: hsa:170691

    STRING: 9606.ENSP00000268070

    UniGene: Hs.513200