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ADCY1 Antibody

  • 货号：
    CSB-PA056130
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA056130(ADCY1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA056130(ADCY1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q08828
  • 基因名：
  • 别名：
    Adenylate cyclase 1; fetal brain; type I antibody; 3',5'-cyclic AMP synthetase antibody; AC1 antibody; Adcy1 antibody; ADCY1_HUMAN antibody; adenyl cyclase antibody; Adenylate cyclase 1 antibody; adenylate cyclase 1 (brain) antibody; Adenylate cyclase type 1 antibody; Adenylate cyclase type I antibody; Adenylyl cyclase 1 antibody; ATP pyrophosphate lyase antibody; ATP pyrophosphate-lyase 1 antibody; Brain adenylate cyclase 1 antibody; Ca(2+)/calmodulin-activated adenylyl cyclase antibody; deafness; autosomal recessive 44 antibody; DFNB44 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ADCY1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina.
  • 基因功能参考文献：
    1. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. PMID: 28223412
    2. Data show that the adenylate cyclase (AC) pathway as genes relating to the antitumor activity of xanthohumol (XN) against tumor cells, and the pathway regulates various cellular functions via activating protein kinase A (PKA)-dependent phosphorylation. PMID: 28122154
    3. Maps to 7p14.1-q11.22 between D7S2209 and marker D7S2435, maximum Lod score 5 for D7S1818. PMID: 15583425
    4. STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition. PMID: 25591908
    5. AC1 catalytic activity can be adjusted by mediating calmodulin activation of AC1 by reversible methionine oxidation in calmodulin. PMID: 25462816
    6. Increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition. PMID: 25568126
    7. AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2. PMID: 23504261
    8. Compartmentalized AC1-CFTR association is responsible for Ca(2+)/cAMP cross-talk. PMID: 20554763
    9. Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. PMID: 12743114
    10. Transgenic mice overexpressing type-1 adenylyl cyclase in the forebrain show elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory. PMID: 15133516
    11. Expression of sensitization of AC1 involves Galpha(s)-adenylyl cyclase interactions. PMID: 15361543
    12. These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking. PMID: 16531006
    13. Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction. PMID: 17586501
    14. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
    15. Young transgenic mice overexpressing AC1 in the forebrain (AC1+ mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more persistent remote contextual memory. PMID: 19726641

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  • 相关疾病：
    Deafness, autosomal recessive, 44 (DFNB44)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane raft.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 组织特异性：
    Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Brain, retina and adrenal medulla.
  • 数据库链接：

    HGNC: 232

    OMIM: 103072

    KEGG: hsa:107

    STRING: 9606.ENSP00000297323

    UniGene: Hs.192215