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ADCY10 Antibody

  • 货号：
    CSB-PA839393LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA839393LA01HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADCY10 Polyclonal antibody
  • Uniprot No.：
    Q96PN6
  • 基因名：
  • 别名：
    ADCY10 antibody; SAC antibody; Adenylate cyclase type 10 antibody; EC 4.6.1.1 antibody; AH-related protein antibody; Adenylate cyclase homolog antibody; Germ cell soluble adenylyl cyclase antibody; hsAC antibody; sAC antibody; Testicular soluble adenylyl cyclase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Adenylate cyclase type 10 protein (897-1136AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ADCY10 Antibody (CSB-PA839393LA01HU)，的标记方式是Non-conjugated。对于ADCY10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839393LB01HU ADCY10 Antibody, HRP conjugated ELISA
    FITC CSB-PA839393LC01HU ADCY10 Antibody, FITC conjugated
    Biotin CSB-PA839393LD01HU ADCY10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation.
  • 基因功能参考文献：
    1. results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition. PMID: 26961873
    2. The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption. PMID: 26857816
    3. Evaluation of soluble adenylyl cyclase expression using R21 antibody is a useful diagnostic adjunct in the evaluation of margins of LM during slow Mohs surgery. PMID: 24698940
    4. shows that in fibroblast cultures inhibition by KH7 of production in the mitochondrial matrix by soluble adenylyl cyclase PMID: 25409931
    5. Crystal structures of human ADCY10 catalytic domains in complex with nucleotides. PMID: 25040695
    6. Soluble adenylyl cyclase plays a role in the regulation of basal cCMP and cUMP. PMID: 24792377
    7. sAC is a regulator of gene expression involved in aldosterone signaling and an important regulator of endothelial stiffness. PMID: 24420537
    8. sAC is necessary for normal glucose-stimulated insulin secretion in vitro and in vivo. PMID: 24100033
    9. a haem-binding domain within the C-terminus of the human soluble adenylate cyclase PMID: 22775536
    10. Significant overexpression of soluble type 10 adenylyl cyclase (sAC), an alternative source of cAMP, was found in human prostate carcinoma. PMID: 23255611
    11. Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. PMID: 21994938
    12. sAC may play a role in the pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression PMID: 20130594
    13. Soluble adenylyl cyclase is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency. PMID: 17591988
    14. These results show that bicarbonate-controlled sAC stimulation must be taken into account in cell physiology and that basal CFTR expression depends on an ionic parameter. PMID: 18209474
    15. a modest association between an ADCY10 polymorphism and the spinal areal BMD in premenopausal white women. PMID: 19093065

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  • 相关疾病：
    Hypercalciuria absorptive 2 (HCA2)
  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Cell projection, cilium. Cytoplasm. Mitochondrion.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 组织特异性：
    Detected in airway epithelial cells and testis (at protein level). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial c
  • 数据库链接：

    HGNC: 21285

    OMIM: 143870

    KEGG: hsa:55811

    STRING: 9606.ENSP00000356825

    UniGene: Hs.320892