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ADCY9 Antibody

  • 货号：
    CSB-PA006850
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using A Cyclase IX Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O60503
  • 基因名：
  • 别名：
    ADCY 9 antibody; ADCY9 antibody; ADCY9_HUMAN antibody; Adenylate cyclase 9 antibody; Adenylate cyclase type 9 antibody; Adenylate cyclase type IX antibody; Adenylyl cyclase 9 antibody; ATP pyrophosphate lyase 9 antibody; ATP pyrophosphate-lyase 9 antibody; KIAA0520 antibody; Type IX adenylyl cyclase antibody; Type IX ATP pyrophosphate lyase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human A Cyclase IX.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors.
  • 基因功能参考文献：
    1. ADCY9 immunoreactivity score was significantly higher (P=0.002) in tumor tissues (6.40+/-1.26, n=200) than in adjacent normal samples (4.13+/-0.83, n=8). The IRS and mRNA expression of ADCY9 were correlated to colon cancer TNM staging. PMID: 29292367
    2. polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers PMID: 28076799
    3. The effects of dalcetrapib on atherosclerotic outcomes are determined by correlated polymorphisms in the ADCY9 gene. PMID: 25583994
    4. The importance of miR-181a-mediated AC9 downregulation in acute promyelocytic leukemia, is reported. PMID: 24722286
    5. Data indicate that adenylyl cyclase 9 (AC9) transcript is a direct target of miR-181b. PMID: 24269684
    6. in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation. PMID: 22778270
    7. The HIV-1 regulatory protein Tat was shown to inhibit the activity of adenylyl cyclase in rat microglial cells. PMID: 11299302
    8. A case-control study using Ile772Met and a repeat (TTTA)n showed no significant association with mood disorders in Japan. PMID: 11840511
    9. associated with bipolar disorder using pedigree linkage disequilibrium PMID: 12082561
    10. blocking glycosylation of AC9 significantly attenuates Galpha(s) stimulation. PMID: 14996950

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 组织特异性：
    Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta. Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.
  • 数据库链接：

    HGNC: 240

    OMIM: 603302

    KEGG: hsa:115

    STRING: 9606.ENSP00000294016

    UniGene: Hs.391860