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ADK Antibody

  • 货号：
    CSB-PA346232LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate, Rat kidney tissue, Rat liver tissue, Mouse kideny tissue, Mouse liver tissue
      All lanes: ADK antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41, 39, 35, 37 kDa
      Observed band size: 41 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA346232LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA346232LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA346232LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADK Polyclonal antibody
  • Uniprot No.：
    P55263
  • 基因名：
    ADK
  • 别名：
    2310026J05Rik antibody; 5033405D03Rik antibody; Adenosine 5''-phosphotransferase antibody; Adenosine kinase antibody; adk antibody; ADK_HUMAN antibody; AI255373 antibody; AI987814 antibody; AK antibody; MGC6593 antibody; OTTHUMP00000019864 antibody; OTTHUMP00000019865 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Adenosine kinase protein (18-256AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ADK Antibody (CSB-PA346232LA01HU)，的标记方式是Non-conjugated。对于ADK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA346232LB01HU ADK Antibody, HRP conjugated ELISA
    FITC CSB-PA346232LC01HU ADK Antibody, FITC conjugated
    Biotin CSB-PA346232LD01HU ADK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
  • 基因功能参考文献：
    1. The results of this study showed that over-expression of the major adenosine removing enzyme ADK in reactive astrocytes and subpopulation of remaining neurons in Rasmussen Encephalitis patients plays an important role in the epileptogensis of Rasmussen Encephalitis. PMID: 28789481
    2. rs11001109 rare allele homozygosity is associated with increased risk of post-traumatic epilepsy development after brain injury. PMID: 26040919
    3. The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB. PMID: 25575137
    4. These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis. PMID: 24128682
    5. Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy. PMID: 22092111
    6. The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy. PMID: 21635241
    7. The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep. PMID: 20881134
    8. The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts. PMID: 20698827
    9. Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia. PMID: 12820662
    10. role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID: 18309031
    11. adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples PMID: 18600536
    12. both deoxycytidine kinase and adenosine kinase are involved in this model of ADA deficiency PMID: 18600545
    13. This study reports for the first time subcellular localization of the enzyme AdK in mammalian cells. PMID: 19635462

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  • 相关疾病：
    Hypermethioninemia due to adenosine kinase deficiency (HMAKD)
  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Carbohydrate kinase PfkB family
  • 组织特异性：
    Widely expressed. Highest level in placenta, liver, muscle and kidney.
  • 数据库链接：

    HGNC: 257

    OMIM: 102750

    KEGG: hsa:132

    STRING: 9606.ENSP00000286621

    UniGene: Hs.656586