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  4. AGAP1 Antibody

AGAP1 Antibody

  • 货号：
    CSB-PA780863
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human liver cancer tissue, hela cells, mouse lung tissue, Primary antibody: CSB-PA780863(AGAP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9UPQ3
  • 基因名：
  • 别名：
    AGAP 1 antibody; AGAP-1 antibody; Agap1 antibody; AGAP1_HUMAN antibody; Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1 antibody; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with GTPase domain ankyrin repeat and PH domain 1 antibody; Centaurin gamma 2 antibody; Centaurin-gamma-2 antibody; CENTG2 antibody; Cnt-g2 antibody; GGAP 1 antibody; GGAP1 antibody; GTP binding and GTPase activating protein 1 antibody; GTP-binding and GTPase-activating protein 1 antibody; KIAA1099 antibody; MGC71657 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human AGAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
  • 基因功能参考文献：
    1. The effect of AGAP1 Knockdown could be rescued by FLAG-AGAP1, but not by an AGAP1 mutant that did not bind Kif2A efficiently, ArfGAP1-HA or Kif2A-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement. PMID: 27531749
    2. GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. PMID: 22453919
    3. overexpression inhibited formation of platelet-derived growth factor-induced ruffles and also induced loss of actin stress fibers PMID: 12388557
    4. AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase PMID: 15381706
    5. CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism. PMID: 15892143
    6. The AGAP1 has been found to associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosomes. PMID: 16079295
    7. AGAP1 is unique among the AZAPs in its specificity for Arf1, and this activity is dependent on its NH(2)-terminal GTPase-like domain. AGAP1 induce reciprocal activation of Arf6. PMID: 18003747

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  • 亚细胞定位：
    Cytoplasm. Note=Associates with the endocytic compartment.
  • 蛋白家族：
    Centaurin gamma-like family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 16922

    OMIM: 608651

    KEGG: hsa:116987

    STRING: 9606.ENSP00000307634

    UniGene: Hs.435039