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AGFG1 Antibody

  • 货号：
    CSB-PA030856
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA030856(AGFG1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA030856(AGFG1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A172 cells, Hela cells, 293T cells, K562 cells, human testis tissue, Primary antibody: CSB-PA030856(AGFG1 Antibody) at dilution 1/533, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P52594
  • 基因名：
    AGFG1
  • 别名：
    AGFG1 antibody; AGFG1_HUMAN antibody; Arf-GAP domain and FG repeats-containing protein 1 antibody; ArfGAP with FG repeats 1 antibody; AU045498 antibody; C130049H11Rik antibody; C85612 antibody; D730048C23Rik antibody; DKFZp686I15205 antibody; HIV 1 Rev binding protein antibody; HIV-1 Rev-binding protein antibody; HRB antibody; MGC116375 antibody; MGC116938 antibody; MGC116940 antibody; Nucleoporin like protein RIP antibody; Nucleoporin-like protein RIP antibody; RAB antibody; Rev interacting protein antibody; Rev-interacting protein antibody; Rev/Rex activation domain-binding protein antibody; RIP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human AGFG1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
  • 基因功能参考文献：
    1. Necroptotic RIP1 phosphorylation and ubiquitination seem to be tightly coordinated: inhibition or absence of RIP1 kinase activity blocks necroptotic RIP1 ubiquitination, whereas mutation of RIP1 necroptosis-associated ubiquitination site (K115R) dampens RIP1 kinase activity during necroptotic signaling. PMID: 27518435
    2. HRB knock-down affected CD4 downregulation induced by Nef but not by HIV-1 Vpu. PMID: 26701340
    3. Selenite caused CYLD upregulation via LEF1 and cIAP downregulation, both of which contribute to the degradation of ubiquitin chains on RIP1 and subsequent caspase-8 activation and colorectal tumor cell apoptosis. PMID: 24577083
    4. The top primary GWAS association of Airway hyperresponsiveness was in rs6731443 (P-value 2.5E-06) located within the AGFG1 genes. PMID: 23984888
    5. Association ofalpha-synuclein with Rab attachment receptor protein and soluble sensitive factor attachment receptors (SNAREs) highlights a key role for membrane transport defects in alpha-synuclein-mediated pathology. PMID: 21439320
    6. The s show that cells lacking functional HRB have significantly reduced production of influenza virus progeny and that this defect results from impaired viral ribonucleoprotein (vRNP) delivery to the plasma membrane. PMID: 21752912
    7. hRIP is an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export. PMID: 14701878
    8. Study demonstrates that the clathrin-mediated endocytosis of the SNARE VAMP7 is directly mediated by Hrb, a clathrin adaptor and ArfGAP. PMID: 18775314
    9. HRB is involved in clathrin-dependent endocytosis and recruits TI-VAMP in this process PMID: 18819912

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  • 亚细胞定位：
    Nucleus. Cytoplasmic vesicle.
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 5175

    OMIM: 600862

    KEGG: hsa:3267

    STRING: 9606.ENSP00000387282

    UniGene: Hs.352962