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AGK Antibody

  • 货号：
    CSB-PA706634LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Mouse kidney tissue, Mouse stomach tissue
      All lanes: AGK antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 48, 8 kDa
      Observed band size: 48 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA706634LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA706634LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AGK Polyclonal antibody
  • Uniprot No.：
    Q53H12
  • 基因名：
    AGK
  • 别名：
    2610037M15Rik antibody; 6720408I04Rik antibody; Acylglycerol Kinase antibody; Acylglycerol kinase mitochondrial antibody; Acylglycerol kinase; mitochondrial antibody; agk antibody; AGK_HUMAN antibody; AI465370 antibody; FLJ10842 antibody; hAGK antibody; HsMuLK antibody; MuLK antibody; Multi substrate lipid kinase antibody; Multi-substrate lipid kinase antibody; Multiple substrate lipid kinase antibody; RGD1562046 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Acylglycerol kinase, mitochondrial protein (32-65AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AGK Antibody (CSB-PA706634LA01HU)，的标记方式是Non-conjugated。对于AGK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA706634LB01HU AGK Antibody, HRP conjugated ELISA
    FITC CSB-PA706634LC01HU AGK Antibody, FITC conjugated
    Biotin CSB-PA706634LD01HU AGK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide. Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol. Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.
  • 基因功能参考文献：
    1. The dual function of AGK as lipid kinase and constituent of the TIM22 complex reveals that disturbances in both phospholipid metabolism and mitochondrial protein biogenesis contribute to the pathogenesis of Sengers syndrome. PMID: 28712724
    2. Identify AGK as a bona fide subunit of TIM22 providing an exciting and unexpected link between mitochondrial protein import and Sengers syndrome. PMID: 28712726
    3. Acylglycerol kinase functions as an oncogene and an unfavorable prognostic marker for human gliomas. PMID: 27574811
    4. We showed that AGK was over-expressed in cervical cancer cell lines and clinical tissues, and over-expression of AGK was associated with poor survival outcomes of early-stage CSCC patients. AGK can be used as an independent prognostic marker for early-stage CSCC. PMID: 26662108
    5. Data suggest that acylglycerol kinase (AGK) has potential as a prognostic factor for overall survival in nasopharyngeal carcinoma (NPC). PMID: 26443540
    6. AGK promotes the proliferation and cell cycle progression of oral squamous cell carcinoma. PMID: 25872568
    7. miR-194 could reduce the phosphoinositide 3-kinase (PI3K)/AKT/FoxO3a signaling pathway by suppressing acylglycerol kinase (AGK) directly. PMID: 25960215
    8. findings provide new evidence that AGK plays an important role in promoting angiogenesis and providing resistance to apoptosis in hepatocellular carcinoma PMID: 25474138
    9. compare our findings to those in 21 previously reported AGK mutation-positive Sengers patients, confirming that Sengers syndrome is a clinically recognisable disorder of mitochondrial energy metabolism PMID: 25208612
    10. AGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1. PMID: 24886245
    11. Our findings suggest that ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy. PMID: 22864860
    12. AGK expression was significantly correlated with JAK2/STAT3 hyperactivation in esophageal squamous cell carcinoma, as well as in lung and breast cancer. PMID: 23676499
    13. study reports 2 families with Sengers syndrome and mutations in the acylglycerol kinase gene; 1 proband had abnormal mitochondria with citrate synthase crystals, associated with high citrate synthase activity; these pedigrees confirm that mutation of AGK is responsible for the severe neonatal presentation of Sengers syndrome PMID: 23266196
    14. This is the first mutation in AGK gene to be implicated in the development of isolated cataract. PMID: 22415731
    15. The loss of AGK led to a decrease of the adenine nucleotide translocator in the inner mitochondrial membrane in muscle. PMID: 22284826
    16. Recessive mutations in AGK cause mitochondrial DNA depletion PMID: 22277967
    17. Lack of the AGK causes Sengers syndrome PMID: 22284826
    18. identification and characterization of a novel lipid kinase that phosphorylates multiple substrates, MuLK PMID: 15252046
    19. The chiral specificity of diacylglycerol kinase alpha, zeta & epsilon mimics the substrate specificity, with MuLK being the least selective and the epsilon isoform of diacylglycerol kinase exhibiting the greatest selectivity. PMID: 18004883
    20. High Expression of acylglycerol kinase is associated with development and progression of prostate cancer. PMID: 19549252

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  • 相关疾病：
    Mitochondrial DNA depletion syndrome 10 (MTDPS10); Cataract 38 (CTRCT38)
  • 亚细胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
  • 蛋白家族：
    AGK family
  • 组织特异性：
    Highly expressed in muscle, heart, kidney and brain.
  • 数据库链接：

    HGNC: 21869

    OMIM: 212350

    KEGG: hsa:55750

    STRING: 9606.ENSP00000347581

    UniGene: Hs.743318