AKAP8 Antibody
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货号:CSB-PA943275
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:O43823
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基因名:
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别名:A kinase (PRKA) anchor protein 8 antibody; A kinase anchor protein 8 antibody; A kinase anchor protein 95 antibody; A kinase anchor protein 95 kDa antibody; A kinase anchor protein 95kDa antibody; A-kinase anchor protein 8 antibody; A-kinase anchor protein 95 kDa antibody; AKAP 8 antibody; AKAP 95 antibody; AKAP-8 antibody; AKAP-95 antibody; Akap8 antibody; AKAP8_HUMAN antibody; AKAP95 antibody; DKFZp586B1222 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Synthetic peptide of Human AKAP8
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,WB,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 IHC 1:25-1:100 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. I...显示更多
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基因功能参考文献:
- These results establish AKAP95 as a mostly positive regulator of pre-mRNA splicing and a possible integrator of transcription and splicing regulation. PMID: 27824034
- Results suggest that ALK generated by alternative transcription Initiation induces chromatin structural changes and heterochromatinization through phosphorylation of AKAP8 in the nucleus. PMID: 29093346
- Using a BioID proximity-based proteomic screen, we identify the nuclear pore complex protein TPR as a novel AKAP95 binding partner. We show interaction between AKAP95 and TPR in mitosis, and an AKAP95-dependent enrichment of TPR in the spindle microtubule area in metaphase, then later in the spindle midzone area. PMID: 28379780
- Report expression of connexin 43 in ovarian cancer cells in G1/S phase. PMID: 26823747
- The data indicate that AKAP95 is a novel nucleolus-associated protein with a regulatory role on rRNA production. PMID: 26683827
- Gene dosage at 19p13.12, and AKAP8 and/or AKAP8L in particular, play an important role in modulation of head size and may contribute to autism risk. PMID: 26076356
- These results suggest that AKAP8 is involved in the regulation of chromatin structural changes through nuclear tyrosine phosphorylation. PMID: 25770215
- Ectopic AKAP95 stimulates expression of a chromosomal reporter gene in synergy with MLL1 or MLL2, whereas AKAP95 depletion impairs retinoic acid-mediated gene induction in embryonic stem cells PMID: 23995757
- AMY-1 interacts with S-AKAP84 and this protein in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. PMID: 12414807
- role of AKAP95 in DNA replication by providing a scaffold for MCM2 PMID: 12740381
- AKAP95 is a potential carrier protein for active caspase 3 from the cytoplasm into the nuclei in apoptotic cells. PMID: 16227597
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亚细胞定位:Nucleus. Nucleus matrix. Nucleus, nucleolus. Cytoplasm.
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蛋白家族:AKAP95 family
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组织特异性:Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells.
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数据库链接:
HGNC: 378
OMIM: 604692
KEGG: hsa:10270
STRING: 9606.ENSP00000269701
UniGene: Hs.594496