AKAP8L Antibody
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货号:CSB-PA001531GA01HU
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规格:¥3,900
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其他:
产品详情
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Uniprot No.:Q9ULX6
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基因名:
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别名:AKAP8L antibody; NAKAP antibody; NAKAP95 antibody; HRIHFB2018A-kinase anchor protein 8-like antibody; AKAP8-like protein antibody; Helicase A-binding protein 95 antibody; HAP95 antibody; Homologous to AKAP95 protein antibody; HA95 antibody; Neighbor of A-kinase-anchoring protein 95 antibody; Neighbor of AKAP95 antibody
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反应种属:Human,Mouse,Rat
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免疫原:Human AKAP8L
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免疫原种属:Homo sapiens (Human)
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
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产品提供形式:Liquid
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应用范围:ELISA
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Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Req...显示更多
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基因功能参考文献:
- Results indicate that in vitro, the interaction between HA95 and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 rather than by CDK1- or PKC-mediated phosphorylation of LAP2beta PMID: 12950172
- NAKAP-HypA scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in HD PMID: 16391387
- Nuclear PKA C subunit co-locates with HA95 in splicing factor compartments and regulates pre-mRNA splicing, possibly through a cAMP-independent mechanism. PMID: 17594903
- These results infer that RNF43 is a resident protein of the ER and, at least partially, the nuclear membrane, with ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with HAP95. PMID: 18313049
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亚细胞定位:Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm.
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蛋白家族:AKAP95 family
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组织特异性:Ubiquitously expressed. Expressed in the brain cortex (at protein level).
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数据库链接:
HGNC: 29857
OMIM: 609475
KEGG: hsa:26993
STRING: 9606.ENSP00000380557
UniGene: Hs.399800