Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. AMIGO2 Antibody

AMIGO2 Antibody

  • 货号：
    CSB-PA001670GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86SJ2
  • 基因名：
    AMIGO2
  • 别名：
    Adhesion molecule with Ig like domain 2 antibody; ALI 1 antibody; ALI1 antibody; Alivin 1 antibody; Alivin-1 antibody; Alivin1 antibody; AMGO2_HUMAN antibody; AMIGO 2 antibody; AMIGO-2 antibody; Amigo2 antibody; Amphoterin induced gene 2 antibody; Amphoterin induced protein 2 antibody; Amphoterin-induced gene and open reading frame 2 antibody; Amphoterin-induced protein 2 antibody; DEGA antibody; Differentially expressed in gastric adenocarcinoma antibody; Differentially expressed in gastric adenocarcinomas antibody; Transmembrane protein AMIGO 2 antibody; Transmembrane protein AMIGO2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human AMIGO2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
  • 基因功能参考文献：
    1. Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells. PMID: 28272394
    2. this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma. PMID: 29149598
    3. AMIGO2 is an important regulator of the PDK1-Akt pathway. PMID: 26553931
    4. Expression of ali1 promotes depolarization-dependent survival of cerebellar granule neurons. Mouse ali1 mapped to a chromosome 15 locus syntenic to candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. PMID: 12843293
    5. Stable expression of a DEGA/AMIGO-2 antisense construct led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration, and a nearly complete abrogation of tumorigenicity in nude mice. PMID: 15107827

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus.
  • 蛋白家族：
    Immunoglobulin superfamily, AMIGO family
  • 组织特异性：
    Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
  • 数据库链接：

    HGNC: 24073

    OMIM: 615690

    KEGG: hsa:347902

    STRING: 9606.ENSP00000266581

    UniGene: Hs.121520