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AMOTL2 Antibody

  • 货号：
    CSB-PA809099NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, PC3 whole cell lysate
      All lanes: AMOTL2 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 86, 92 kDa
      Observed band size: 86 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AMOTL2 Polyclonal antibody
  • Uniprot No.：
    Q9Y2J4
  • 基因名：
    AMOTL2
  • 别名：
    AMOL2_HUMAN antibody; Amotl2 antibody; angiomotin like 2 antibody; Angiomotin-like protein 2 antibody; KIAA0989 antibody; LCCP antibody; Leman coiled coil protein antibody; Leman coiled-coil protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Angiomotin-like protein 2 protein (718-737AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AMOTL2 Antibody (CSB-PA809099NA01HU)，的标记方式是Non-conjugated。对于AMOTL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA809099NB01HU AMOTL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA809099NC01HU AMOTL2 Antibody, FITC conjugated
    Biotin CSB-PA809099ND01HU AMOTL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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靶点详情

  • 功能：
    Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
  • 基因功能参考文献：
    1. these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention PMID: 28368415
    2. AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients. PMID: 25080976
    3. These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process. PMID: 23525008
    4. AMOTL2 interacts with TAZ and modulates transcriptional activity of TAZ. PMID: 23911299
    5. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells PMID: 21937427

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  • 亚细胞定位：
    Recycling endosome.
  • 蛋白家族：
    Angiomotin family
  • 数据库链接：

    HGNC: 17812

    OMIM: 614658

    KEGG: hsa:51421

    STRING: 9606.ENSP00000249883

    UniGene: Hs.426312