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AMPD2 Antibody

  • 货号：
    CSB-PA001681LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001681LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA001681LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: U87 whole cell lysate
      All lanes: AMPD2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 101, 93, 89 kDa
      Observed band size: 101 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AMPD2 Polyclonal antibody
  • Uniprot No.：
    Q01433
  • 基因名：
    AMPD2
  • 别名：
    Adenosine monophosphate deaminase 2 (isoform L) antibody; Adenosine monophosphate deaminase 2 antibody; adenosine monophosphate deaminase 2 isoform L antibody; AMP deaminase 2 antibody; AMP deaminase isoform L antibody; AMPD 2 antibody; AMPD antibody; AMPD2 antibody; AMPD2_HUMAN antibody; RP5-1160K1.5 antibody; SPG63 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human AMP deaminase 2 protein (1-129AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AMPD2 Antibody (CSB-PA001681LA01HU)，的标记方式是Non-conjugated。对于AMPD2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001681LB01HU AMPD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA001681LC01HU AMPD2 Antibody, FITC conjugated
    Biotin CSB-PA001681LD01HU AMPD2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
  • 基因功能参考文献：
    1. Here we report the clinical and genetic analysis of an individual with PCH9 secondary to a novel missense variant with strong evidence of pathogenicity, located outside the catalytic domain of AMPD2 PMID: 28168832
    2. tofacitinib increases the cellular levels of adenosine, which is known to have anti-inflammatory activity, through the downregulation of AMPD2. This would be a novel functional aspect of tofacitinib. PMID: 25496463
    3. In human HepG2 cells, AMPD2 activation counterregulates AMPK and increases intracellular glucose production, in association with up-regulation of PEPCK and G6Pc. PMID: 24755741
    4. Study concluded that AMPD2 as necessary for guanine nucleotide biosynthesis and protein translation and provide evidence that AMP deaminase activity is critical during neurogenesis. Patients with mutations in AMPD2 have characteristic brain imaging features of pontocerebellar hypoplasia due to loss of brainstem and cerebellar parenchyma. PMID: 23911318
    5. N-terminal extensions of the AMPD2 polypeptide influence ATP regulation of isoform L. PMID: 12745092

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  • 相关疾病：
    Pontocerebellar hypoplasia 9 (PCH9); Spastic paraplegia 63, autosomal recessive (SPG63)
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family
  • 组织特异性：
    Highly expressed in cerebellum.
  • 数据库链接：

    HGNC: 469

    OMIM: 102771

    KEGG: hsa:271

    STRING: 9606.ENSP00000256578

    UniGene: Hs.82927