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AMPH Antibody

  • 货号：
    CSB-PA011032
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using Amphiphysin I Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using Amphiphysin I Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P49418
  • 基因名：
  • 别名：
    Amp antibody; AMPH 1 antibody; AMPH antibody; AMPH_HUMAN antibody; AMPH1 antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kD autoantigen) antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) antibody; Amphiphysin antibody; Amphiphysin I antibody; CG8604 antibody; Damp antibody; dAmph antibody; Dmel\CG8604 antibody; HGNC:471 antibody; MGC49429 antibody; Stiff man syndrome with breast cancer 128kD autoantigen antibody; Stiff man syndrome with breast cancer 128kDa autoantigen antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Amphiphysin I.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
  • 基因功能参考文献：
    1. The data show that the dynamin-amphiphysin helices are rearranged to form clusters upon GTP hydrolysis and membrane constriction occurs at protein-uncoated regions flanking the clusters. PMID: 29357276
    2. We show that AMPH-1/BIN1 binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies. PMID: 26506308
    3. It is a nerve protein and its autoantibody causes paraneoplastic neurological syndromes. PMID: 25087559
    4. AMPH1 protein level is reduced in transgenic mouse brain proteins. in the brainstem of nontransgenic and terminally ill JNPL3 transgenic mice. PMID: 22975846
    5. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome PMID: 22331304
    6. structure-based approach to prediction of peptide-binding behavior of SH3 domain of amphiphysin-1: statistical modeling PMID: 19669081
    7. investigation of binding affinities of decapeptide ligands with amphiphysin SH3 domain using QSAR models PMID: 20214647
    8. Female patient with amphiphysin autoantibodies and siff leg syndrome due to small cell cancer of the lung. PMID: 16671079
    9. Amphiphysin I (Amph I) is a minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase substrate. Amph I phosphorylation changes the recruitment of endophilin at the endocytic sites. PMID: 16733250
    10. This study demonstrates that the analysis of the molecular interaction energy components between peptides and the SH3 domain can successfully characterize the binding interface. PMID: 18206907
    11. Analyses of Gaussian distribution models showed that diversified properties contribute to the interactions between the SH3 domain and of amphiphysin and peptides. PMID: 18814309

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Neurons, certain endocrine cell types and spermatocytes.
  • 数据库链接：

    HGNC: 471

    OMIM: 600418

    KEGG: hsa:273

    STRING: 9606.ENSP00000348602

    UniGene: Hs.592182