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AMTN Antibody

  • 货号：
    CSB-PA001685LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA001685LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AMTN Polyclonal antibody
  • Uniprot No.：
    Q6UX39
  • 基因名：
    AMTN
  • 别名：
    Amelotin antibody; Amtn antibody; AMTN_HUMAN antibody; RSTI689 antibody; UNQ689 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Amelotin protein (17-209AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AMTN Antibody (CSB-PA001685LA01HU)，的标记方式是Non-conjugated。对于AMTN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001685LB01HU AMTN Antibody, HRP conjugated ELISA
    FITC CSB-PA001685LC01HU AMTN Antibody, FITC conjugated
    Biotin CSB-PA001685LD01HU AMTN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
  • 基因功能参考文献：
    1. TNF-alpha stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter. PMID: 29282478
    2. Results show that AMTN and KLK4 are not essential for biological processes outside of the dentition or during the secretory stage of amelogenesis. Both KLK4 and AMTN proved to be essential for the maturation of dental enamel, a process that requires the removal of extracellularmatrix proteins and the deposition of ions on the sides of enamel crystallites. PMID: 26620968
    3. This study demonstrates for the first time that AMTN mutations cause non-syndromic human Amelogenesis imperfecta (AI) and explores the human phenotype, comparing it with that of mice with disrupted Amtn function. PMID: 27412008
    4. AMTN has a direct influence on biomineralization by promoting hydroxyapatite mineralization. PMID: 25407797
    5. proinflammatory cytokines induce Amelotin gene transcription and a role for Amelotin in gingival inflammation PMID: 25158173

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  • 相关疾病：
    Amelogenesis imperfecta 3B (AI3B)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Amelotin family
  • 数据库链接：

    HGNC: 33188

    OMIM: 610912

    KEGG: hsa:401138

    STRING: 9606.ENSP00000341013

    UniGene: Hs.453069