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ANAPC10 Antibody

  • 货号：
    CSB-PA892350ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA892350ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA892350ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ANAPC10 Polyclonal antibody
  • Uniprot No.：
    Q9UM13
  • 基因名：
  • 别名：
    ANAPC 10 antibody; anapc10 antibody; Anaphase promoting complex 10 antibody; Anaphase promoting complex subunit 10 antibody; Anaphase-promoting complex subunit 10 antibody; Apc 10 antibody; APC10 antibody; APC10_HUMAN antibody; Cyclosome subunit 10 antibody; DKFZP564L0562 antibody; Doc 1 antibody; Doc1 antibody; Doc1; S. cerevisiae; homolog of antibody; OTTHUMP00000220297 antibody; OTTHUMP00000220298 antibody; OTTHUMP00000220299 antibody; OTTHUMP00000220300 antibody; OTTHUMP00000220303 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Anaphase-promoting complex subunit 10 protein (1-185AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能参考文献：
    1. Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A PMID: 21336306
    2. Substrates are recruited to the Anaphase-promoting complex by binding to a bipartite substrate receptor composed of Cdh1 and Doc1. PMID: 21186364
  • 蛋白家族：
    APC10 family
  • 数据库链接：

    HGNC: 24077

    OMIM: 613745

    KEGG: hsa:10393

    STRING: 9606.ENSP00000310071

    UniGene: Hs.480876