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ANLN Antibody

  • 货号：
    CSB-PA168510
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA168510(ANLN Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NQW6
  • 基因名：
    ANLN
  • 别名：
    Actin binding protein scraps homolog Drosophila antibody; Actin binding protein anillin antibody; Actin-binding protein anillin antibody; Anillin actin binding protein antibody; anln antibody; ANLN_HUMAN antibody; DKFZp779A055 antibody; FSGS8 antibody; Scra antibody; Scraps antibody; Scraps homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ANLN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
  • 基因功能参考文献：
    1. Bladder urothelial carcinoma patients with elevated ANLN expression had poorer survival prospects. PMID: 28600503
    2. Knockdown of ANLN in liver cells blocks cytokinesis and inhibits development of liver tumors. PMID: 29274368
    3. s found that decreasing Ran-GTP levels or tethering active Ran to the equatorial membrane affects anillin's localization and causes cytokinesis phenotypes. PMID: 28931593
    4. Anillin (ANLN) expression in tumor cells is correlated to poor prognosis in breast cancer patients, independent of Ki-67 or tumor size. PMID: 27863473
    5. S635 phosphorylation is essential for cytokinesis. PMID: 28081137
    6. ANLN expression is elevated in colorectal cancer and has a strong potential to act as a biomarker for the prognosis of colorectal cancer. PMID: 27062703
    7. Findings indicate that miR-497 is a potent tumor suppressor that inhibits cancer phenotypes by targeting ANLN and HSPA4L in NPC. PMID: 26486082
    8. High nuclear expression of anillin (ANLN) is an independent predictor of poor disease-specific survival and it is a useful prognostic marker of urothelial carcinoma of the upper urinary tract (UCUT). PMID: 26135313
    9. Data suggest that anillin (ANLN) could be involved in breast cancer progression and a potential target candidate in breast cancer. PMID: 25223638
    10. Identification 4 novel and 18 known exonic ANLN variants associated with carotid intima-media thickness at bifurcation. PMID: 26319989
    11. Anillin regulates intercellular adhesion in model human epithelia by mechanisms involving the suppression of JNK activity and controlling the assembly of the perijunctional cytoskeleton. PMID: 25809162
    12. The sequestration of anillin by astral microtubules might alter the organization of cortical proteins to polarize cells for cytokinesis PMID: 24994938
    13. these data demonstrate that a complex of p190RhoGAP-A and anillin modulates RhoA-GTP levels in the cytokinetic furrow to ensure progression of cytokinesis. PMID: 25359885
    14. Identified a missense mutation R431C in anillin (ANLN), an F-actin binding cell cycle gene, as a cause of FSGS. We screened 250 additional families with FSGS and found another variant, G618C, that segregates with disease in a second family with FSGS. PMID: 24676636
    15. ANLN is positively associated with Wnt/beta-catenin signaling in gastric cancer.Elevated expression of ANLN is a predictor of intestinal type gastric cancer. ER-alpha is negatively associated with the expression of ANLN in gastric cancer. PMID: 24809965
    16. Supervillin concentrates activated and total myosin II at the furrow, and simultaneous knockdown of supervillin and anillin additively increases cell division failure. PMID: 24088567
    17. Antibody screening revealed 3 candidate prognostic markers in breast cancer: the Anillin (ANLN); PDZ-Binding Kinase (PBK); and, PDZ-Domain Containing 1 (PDZK1). PMID: 23547718
    18. Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex. PMID: 22514687
    19. CIT-K is capable of physically and functionally interacting with the actin-binding protein anillin. PMID: 21849473
    20. Cytoplasmic anillin expression is a marker of favourable prognosis in renal cell carcinoma patients. PMID: 21109967
    21. This study was to establish if ANLN was a molecular marker for pancreatic cancer. PMID: 19995712
    22. anillin has a role in spatially regulating the contractile activity of myosin II during cytokinesis PMID: 15496454
    23. Anillin is a substrate of APC/C that controls spatial contractility of myosin during late cytokinesis. PMID: 16040610
    24. anillin is overexpressed in diverse common human tumors, but not simply because of its role in cell proliferation PMID: 16203764
    25. Over-expression of ANLN is associated with pulmonary carcinogenesis PMID: 16357138
    26. Human anillin contains a conserved C-terminal domain that is essential for its function and localization. PMID: 18158243

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  • 相关疾病：
    Focal segmental glomerulosclerosis 8 (FSGS8)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell projection, bleb. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
  • 组织特异性：
    Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and
  • 数据库链接：

    HGNC: 14082

    OMIM: 616027

    KEGG: hsa:54443

    STRING: 9606.ENSP00000265748

    UniGene: Hs.62180