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  4. ANP32B Antibody

ANP32B Antibody

  • 中文名称：
    ANP32B兔多克隆抗体
  • 货号：
    CSB-PA001823GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q92688
  • 基因名：
    ANP32B
  • 别名：
    Acidic (leucine rich) nuclear phosphoprotein 32 family member B antibody; Acidic leucine rich nuclear phosphoprotein 32 family member B antibody; Acidic leucine-rich nuclear phosphoprotein 32 family member B antibody; Acidic nuclear phosphoprotein 32 family member B antibody; Acidic protein rich in leucines antibody; AN32B_HUMAN antibody; ANP 32B antibody; ANP32B antibody; APRIL antibody; OTTHUMP0000006377 antibody; PAL 31 antibody; PAL31 antibody; PHAPI 2 antibody; PHAPI2 antibody; PHAPI2 protein antibody; PHAPI2a antibody; Proliferation related acidic leucine rich protein antibody; Putative HLA-DR-associated protein I-2 antibody; Silver stainable protein SSP 29 antibody; Silver stainable protein SSP29 antibody; Silver-stainable protein SSP29 antibody; Ssp 29 antibody; Ssp29 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ANP32B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis. Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Plays also an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1. Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation.; (Microbial infection) Plays an essential role in influenza A and B viral genome replication. Plays also a role in foamy virus mRNA export from the nucleus to the cytoplasm.
  • 基因功能参考文献：
    1. According to the cellular function of the characterized targets of ProTalpha, and the evolution in the composition of the diverse ProTalpha-complexes when proliferation activity was reduced or apoptosis induced, leads to hypothesized that ProTalpha interactions might be related to the proliferation activity and control of the cell survival. PMID: 29106904
    2. ANP32B modulates Bad phosphorylation as well as Bak and Bax expression, resulting in regulation of apoptosis in HCC. These findings indicate the potential value of ANP32B as a therapeutic target for HCC PMID: 28486557
    3. Caspase-3-resistant uncleavable form of acidic leucine-rich nuclear phosphoprotein 32B potentiates leukemic cell apoptosis. PMID: 25483709
    4. ANP32B is a nuclear target of henipavirus M proteins. PMID: 24823948
    5. this is the first demonstration that ANP32B expression was down-regulated during differentiation induction of leukemic cells by all-trans retinoic acid. PMID: 22705300
    6. the interaction of ANP32B with the core histones H3-H4 occurs on its concave side, and both the acidic and hydrophobic residues that compose the concave surface are critical for histone binding. PMID: 20538007
    7. ANP32B is a direct substrate of caspase-3. It is cleaved at the sequence of Ala-Glu-Val-Asp, after Asp-163. The reduced expression of endogenous ANP32B by specific siRNA enhances caspase-3 activation & apoptosis induction by NSC606985 & etoposide. PMID: 20015864
    8. regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis PMID: 12522243
    9. recruitment of ANP32B onto the promoter region requires KLF5 and results in promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B PMID: 18039846
    10. The CK2 alpha' phosphorylates APRIL and therefore is responsible for the regulation of the nucleocytoplasmic translocation of CD83 mRNA. PMID: 19130553

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  • 亚细胞定位：
    [Isoform 1]: Nucleus. Cytoplasm.; [Isoform 2]: Cytoplasm. Note=Lacks a nuclear localization signal.
  • 蛋白家族：
    ANP32 family
  • 组织特异性：
    Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
  • 数据库链接：

    HGNC: 16677

    KEGG: hsa:10541

    STRING: 9606.ENSP00000345848

    UniGene: Hs.730654