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AOAH Antibody

  • 货号：
    CSB-PA001853LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in:Mouse Brain tissue lysate
      All lanes: AOAH antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 66 kDa
      Observed band size: 66 kDa
    • IHC image of CSB-PA001853LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

产品详情

  • 产品描述：

    CUSABIO produces the product (CSB-PA623900LA01HU) by immunizing rabbits with the peptide corresponding to amino acids 131-332 of the recombinant human LRP8. The anti-LRP8 antibody is eventually purified from rabbit antiserum by protein G affinity chromatography. Its purity is greater than 95%. It occurs as an unconjugated IgG. And it only reacts with human LRP8 protein. This LRP8 polyclonal antibody is suitable for the detection of LRP8 protein in ELISA, WB, and IF applications.

    The LRP8 protein, also known as apolipoprotein E receptor 2 (APOER2), regulates the uptake and clearance of lipoproteins and mediates signaling events in response to extracellular ligands, with important implications for brain development and function, as well as for metabolic disorders and neurodegenerative diseases.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AOAH Polyclonal antibody
  • Uniprot No.：
    P28039
  • 基因名：
    AOAH
  • 别名：
    Acyloxyacyl hydrolase (neutrophil) antibody; Acyloxyacyl hydrolase large subunit antibody; AOAH antibody; AOAH_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Acyloxyacyl hydrolase protein (180-254AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AOAH Antibody (CSB-PA001853LA01HU)，的标记方式是Non-conjugated。对于AOAH Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001853LB01HU AOAH Antibody, HRP conjugated ELISA
    FITC CSB-PA001853LC01HU AOAH Antibody, FITC conjugated
    Biotin CSB-PA001853LD01HU AOAH Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    Application:ELISA, Mouse(WB),Human(IHC)
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses. In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria.
  • 基因功能参考文献：
    1. analysis of AOAH function through its crystal structure and complex with lipopolysaccharide PMID: 29343645
    2. AOAH - Gene involved in innate immunity that have been associated with Chronic Rhinosinusitis. PMID: 27888910
    3. AOAH rs60023210 variants may be associated with carotid intima-media thickness at bifurcation. PMID: 26319989
    4. Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population. PMID: 22723975
  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle.
  • 数据库链接：

    HGNC: 548

    OMIM: 102593

    KEGG: hsa:313

    STRING: 9606.ENSP00000258749

    UniGene: Hs.488007