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AP1M2 Antibody

  • 货号：
    CSB-PA895771ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: AP1M2 antibody at 2μg/ml
      Lane 1: Mouse small intestine tissue
      Lane 2: Mouse kidney tisueSecondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 48 kDa
      Observed band size: 48 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA895771ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA895771ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AP1M2 Polyclonal antibody
  • Uniprot No.：
    Q9Y6Q5
  • 基因名：
    AP1M2
  • 别名：
    Adaptor protein complex AP-1 mu-2 subunit antibody; Adaptor protein complex AP1 mu2 subunit antibody; Adaptor related protein complex 1 mu2 subunit antibody; Adaptor-related protein complex 1 mu-2 subunit antibody; AP mu chain family member mu1B antibody; AP-1 complex subunit mu-2 antibody; AP-mu chain family member mu1B antibody; AP1 complex subunit mu2 antibody; AP1M2 antibody; AP1M2_HUMAN antibody; AP47 2 antibody; Clathrin assembly protein complex 1 medium chain 2 antibody; Golgi adaptor HA1/AP1 adaptin mu-2 subunit antibody; Golgi adaptor HA1/AP1 adaptin mu2 subunit antibody; HA1 47 kDa subunit 2 antibody; HSMU1B antibody; MU 1B antibody; Mu adaptin 2 antibody; Mu-adaptin 2 antibody; Mu1B adaptin antibody; Mu1B-adaptin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human AP-1 complex subunit mu-2 protein (164-423AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
  • 基因功能参考文献：
    1. Variants in AP1M2 gene is associated with thrombosis. PMID: 26908601
    2. Results suggest that mu1B interacts with different classes of basolateral targeting signals in distinct ways. PMID: 12134076
    3. The AP1M2 gene was shown to effectively separate these two tumor(chromophobe renal cell carcinoma (RCC) and benign oncocytoma) groups by quantitative reverse transcription-PCR using fresh tissue samples, with similar trends seen on formalin-fixed tissues. PMID: 17145811
    4. PIPKIgamma also interacts with the mu subunits of clathrin adaptor protein (AP) complexes PMID: 17261850
    5. The mechanism of iron absorption from mineralized Soybean ferritin using Caco-2 cells via a mu2-dependent endocytosis mechanism is reported. PMID: 18356317

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  • 亚细胞定位：
    Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • 蛋白家族：
    Adaptor complexes medium subunit family
  • 数据库链接：

    HGNC: 558

    OMIM: 607309

    KEGG: hsa:10053

    STRING: 9606.ENSP00000250244

    UniGene: Hs.18894