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AP4B1 Antibody

  • 货号：
    CSB-PA897585LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: AP4B1 antibody at 3μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: U251 whole cell lysate
      Lane 3: LO2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 84, 35 kDa
      Observed band size: 84 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA897585LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA897585LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AP4B1 Polyclonal antibody
  • Uniprot No.：
    Q9Y6B7
  • 基因名：
    AP4B1
  • 别名：
    AP4B1AP-4 complex subunit beta-1 antibody; AP-4 adaptor complex subunit beta antibody; Adaptor-related protein complex 4 subunit beta-1 antibody; Beta subunit of AP-4 antibody; Beta4-adaptin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human AP-4 complex subunit beta-1 protein (201-500AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AP4B1 Antibody (CSB-PA897585LA01HU)，的标记方式是Non-conjugated。对于AP4B1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897585LB01HU AP4B1 Antibody, HRP conjugated ELISA
    FITC CSB-PA897585LC01HU AP4B1 Antibody, FITC conjugated
    Biotin CSB-PA897585LD01HU AP4B1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
  • 基因功能参考文献：
    1. Novel homozygous 2-bp deletion in AP4B1 was found in siblings with intellectual disability and spastic tetraplegia. PMID: 24781758
    2. Data suggest that AP4B1 mutations cause spastic paraplegia type 47 and should be considered in early onset spastic paraplegia with intellectual disability. PMID: 22290197
  • 相关疾病：
    Spastic paraplegia 47, autosomal recessive (SPG47)
  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
  • 蛋白家族：
    Adaptor complexes large subunit family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 572

    OMIM: 607245

    KEGG: hsa:10717

    STRING: 9606.ENSP00000256658

    UniGene: Hs.515048