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APBA1 Antibody

  • 货号：
    CSB-PA583474
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: CSB-PA583474(APBA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q02410
  • 基因名：
    APBA1
  • 别名：
    Adapter protein X11 alpha antibody; Adapter protein X11alpha antibody; Amyloid beta A4 precursor protein-binding family A member 1 antibody; Apba1 antibody; APBA1_HUMAN antibody; Mint 1 antibody; Mint-1 antibody; Neuron specific X11 protein antibody; Neuron-specific X11 protein antibody; Neuronal Munc18 1 interacting protein 1 antibody; Neuronal Munc18-1-interacting protein 1 antibody; UROP11 antibody; x11 antibody; X11alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human APBA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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靶点详情

  • 功能：
    Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
  • 基因功能参考文献：
    1. Mint1 causes amyloid precursor protein accumulation in the trans-Golgi network. PMID: 26865271
    2. Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production. PMID: 24742670
    3. Mint1 826 bridges APP to the small GTPase PMID: 23737971
    4. an autoinhibitory mechanism in Mint1 is important for regulating APP processing and may provide novel therapies for Alzheimer's disease PMID: 22355143
    5. Transcriptional co-activators Taz and Yap mediate signaling via the amyloid beta protein precursor paralogues APLP1 and APLP2 through interactions with Mint1 and Mint3. PMID: 21178287
    6. Study identified the conserved binding site for the peptide on the CASK calmodulin kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding. PMID: 21763699
    7. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis. PMID: 20531236
    8. Methylation of MINT1 was significantly more prevalent in UC-CRC cases compared with controls. PMID: 20160714
    9. ApoEr2 regulates cell movement, and both X11alpha and Reelin enhance this effect. PMID: 19720620
    10. A novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains of amyloid precursor protein (APP)-interacting proteins Mint1, Mint2, and Mint3 is reported, with multiple novel interactors for these proteins. PMID: 20016085
    11. Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion. PMID: 12016213
    12. Coexpression of X11alpha with amyloid protein precursor retarded its maturation, prolonged its half-life, and inhibited amyloid protein precursor, Abeta40, and Abeta42 secretion. PMID: 12849748
    13. human X11alpha inhibits Abeta production and deposition in vivo in the brain in transgenic mice harboring a familial Alzheimer's disease mutant APP that produces increased levels of Abeta. PMID: 12970358
    14. Involvement of X11L in the phosphorylation of APP family proteins in cellular stress and suggest that X11L protein may be . PMID: 14970211
    15. X11alpha and X11beta have roles in beta-amyloid precursor protein processing PMID: 15699037
    16. Mediates exocytosis and decreases beta-amyloid peptide formation in Alzheimer disease. PMID: 16413130
    17. Data show that neuronal munc18-1-interacting protein 1 is an inclusion body component in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture. PMID: 18836734

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Only about 5% of the protein is located in the nucleus.; [Isoform 2]: Golgi apparatus.
  • 组织特异性：
    Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.
  • 数据库链接：

    HGNC: 578

    OMIM: 602414

    KEGG: hsa:320

    STRING: 9606.ENSP00000265381

    UniGene: Hs.171939