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APBA3 Antibody

  • 货号：
    CSB-PA080020
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O96018
  • 基因名：
    APBA3
  • 别名：
    Adapter protein X11gamma antibody; amyloid beta (A4) precursor protein binding; family A; member 3 antibody; Amyloid beta A4 precursor protein-binding family A member 3 antibody; Amyloid beta precursor protein binding; family A; member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein antibody; APBA3 antibody; APBA3_HUMAN antibody; lin 10 antibody; MGC:15815 antibody; Mint 3 antibody; Mint-3 antibody; Neuron specific X11L2 protein antibody; Neuron-specific X11L2 protein antibody; Neuronal Munc18 1 interacting protein 3 antibody; Neuronal Munc18-1-interacting protein 3 antibody; phosphotyrosine binding/interacting domain (PTB) bearing protein antibody; X11 like 2 protein 2 antibody; X11gamma antibody; X11L2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human X11γ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
  • 基因功能参考文献：
    1. Results suggest that NECAB3, a novel Mint3-binding protein, activates HIF-1 to promote normoxic glycolysis and tumorigenicity by forming a ternary complex with Mint3 and FIH-1. PMID: 26948053
    2. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. PMID: 24867948
    3. Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production. PMID: 24742670
    4. Strict specificity for recruitment of the Mint3 adaptor by APP at the Golgi, a critical role for Tyr-682 (within the YENPTY motif) in Mint3 recruitment and export of APP from the Golgi, are demonstrated. PMID: 23965993
    5. These results indicate that all three amyloid beta protein precursor family members are capable of activating gene transcription via Mint3-Taz and Mint3-Yap. PMID: 21178287
    6. Two transcriptional coactivators, TAZ and YAP, functionally associate with amyloid precursor protein through Mint3 and form transcriptionally active triple protein complexes. PMID: 20016085
    7. Associated with etilogical mechanism of Alzheimer's disease. PMID: 11831025
    8. Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV PMID: 14990567
    9. We have examined the ability of Bcr to interact with other epithelial PDZ proteins and found specific binding to both the apical PDZK1 protein and the Golgi-localized Mint3 PMID: 15494376
    10. These data implicate Mint3 activity as a critical determinant of post-Golgi APP traffic. PMID: 17959829
    11. the interaction between the PTB domain of Mint3 and the acidic peptide signal of Furin regulates the specific localization of Furin in the trans-Golgi network PMID: 18544638
    12. Mint3 regulates the FIH-1-HIF-1 pathway, which controls ATP production in macrophages PMID: 19726677

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed in all tissues examined with lower levels in brain and testis.
  • 数据库链接：

    HGNC: 580

    OMIM: 604262

    KEGG: hsa:9546

    STRING: 9606.ENSP00000315136

    UniGene: Hs.25527