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APBB2 Antibody

  • 货号：
    CSB-PA009249
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q92870
  • 基因名：
    APBB2
  • 别名：
    Amyloid beta (A4) precursor protein-binding; family B; member 2 (Fe65 like) antibody; Amyloid beta A4 precursor protein binding family B member 2 antibody; Amyloid beta A4 precursor protein-binding family B member 2 antibody; APBB 2 antibody; APBB2 antibody; APBB2_HUMAN antibody; Fe65 like 1 antibody; Fe65 like antibody; Fe65 like protein antibody; FE65L 1 antibody; FE65L antibody; FE65L1 antibody; Protein Fe65-like 1 antibody; Rirl 1 antibody; Rirl1 antibody; TR2 L antibody; TR2L antibody; Zfra antibody; Zinc finger like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Fe65L.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength. Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Activates transcription of APP.
  • 基因功能参考文献：
    1. APBB2 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
    2. results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease PMID: 26194614
    3. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability. PMID: 23384821
    4. FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles PMID: 14527950
    5. rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility. PMID: 15714520
    6. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF PMID: 16083851
    7. In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1. PMID: 17567906
    8. The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range. PMID: 18852029
    9. The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell. PMID: 19542221

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  • 亚细胞定位：
    Endoplasmic reticulum. Golgi apparatus. Early endosome.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 582

    OMIM: 602710

    KEGG: hsa:323

    STRING: 9606.ENSP00000427211

    UniGene: Hs.479602