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APCDD1 Antibody

  • 货号：
    CSB-PA814246LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, MCF-7 whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, K562 whole cell lysate
      All lanes: APCDD1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 59 kDa
      Observed band size: 59 kDa
    • IHC image of CSB-PA814246LA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA814246LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) APCDD1 Polyclonal antibody
  • Uniprot No.：
    Q8J025
  • 基因名：
    APCDD1
  • 别名：
    Adenomatosis polyposis coli down regulated 1 antibody; Adenomatosis polyposis coli down regulated 1 protein antibody; Adenomatosis polyposis coli down-regulated 1 protein antibody; APCD1_HUMAN antibody; APCDD 1 antibody; APCDD1 antibody; B7323 antibody; DRAPC1 antibody; FP7019 antibody; HHS antibody; HTS antibody; hypoptrichosis simplex antibody; Protein APCDD1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein APCDD1 protein (22-288AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，APCDD1 Antibody (CSB-PA814246LA01HU)，的标记方式是Non-conjugated。对于APCDD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA814246LB01HU APCDD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA814246LC01HU APCDD1 Antibody, FITC conjugated
    Biotin CSB-PA814246LD01HU APCDD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • 基因功能参考文献：
    1. Thus, we have provided the first evidence that APCDD1 expression is epigenetically silenced in OS, which may facilitate invasion and metastasis of OS cells. PMID: 28698141
    2. these novel findings suggest that APCDD1 positively regulates adipogenic differentiation and that its down-regulation by miR-130 during diet-induced obesity may contribute to impaired adipogenic differentiation and obesity-related metabolic disease. PMID: 28242765
    3. This study demonstrated a critical role for Apcdd1 in OL differentiation after white matter injury that points to a potential therapeutic approach for inhibiting Wnt signaling in these disorders. PMID: 25946682
    4. Unusual role of APCDD1 in dental follicle cells during osteogenic differentiation. APCDD1 sustains the expression and activation of beta-catenin. PMID: 25592970
    5. mutation in the APCDD1 gene is responsible for hereditary hypotrichosis simplex in a large Chinese family. PMID: 22512811
    6. Data show that the methylated VAPA-APCDD1 DNA in maternal plasma is predominantly derived from the fetus, and this novel fetal epigenetic marker in maternal plasma is useful for the noninvasive detection of fetal trisomy 18. PMID: 21152411
    7. APCDD1 is a novel inhibitor of the Wnt signalling pathway with an essential role in human hair growth PMID: 20393562

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  • 相关疾病：
    Hypotrichosis 1 (HYPT1)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    APCDD1 family
  • 组织特异性：
    Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in
  • 数据库链接：

    HGNC: 15718

    OMIM: 605389

    KEGG: hsa:147495

    STRING: 9606.ENSP00000347433

    UniGene: Hs.293274