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API5 Antibody

  • 货号：
    CSB-PA042409
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, MCF7 cells, A549 cells, Lovo cells, Primary antibody: CSB-PA042409(API5 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9BZZ5
  • 基因名：
    API5
  • 别名：
    AAC 11 antibody; AAC-11 antibody; AAC11 antibody; Antiapoptosis clone 11 protein antibody; API 5 antibody; API-5 antibody; api5 antibody; API5 like 1 antibody; API5_HUMAN antibody; API5L1 antibody; Apoptosis inhibitor 5 antibody; Cell migration inducing gene 8 protein antibody; Cell migration-inducing gene 8 protein antibody; Fibroblast growth factor 2 interacting factor 2 antibody; Fibroblast growth factor 2-interacting factor antibody; FIF antibody; MIG 8 antibody; MIG8 antibody; Migration inducing protein MIG8 antibody; Protein XAGL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human API5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
  • 基因功能参考文献：
    1. study demonstrates that apoptosis inhibitor 5 is an endogenous and direct inhibitor of caspase-2. API5 protein directly binds to the caspase recruitment domain (CARD) of caspase-2 and impedes dimerization and activation of caspase-2. PMID: 28336776
    2. s propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1-dependent apoptotic pathway and ensuring viral replication. PMID: 26673663
    3. s show that API5 increases the metastatic capacity of cervical cancer cells in vitro and in vivo via up-regulation of MMP-9. PMID: 25248562
    4. rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes PMID: 25819896
    5. API5 overexpression promoted cell proliferation and colony formation in CaSki cancer cells, whereas API5 knockdown inhibited the both properties in HeLa cells; API5 expression is associated with pERK1/2 in a subset of cervical cancer patients and its expression predicts poor overall survival. PMID: 25070070
    6. miR-143 and miR-145 and the predicted target proteins API5, ERK5, K-RAS, and IRS-1 display regional differences in expression in the colon PMID: 25477374
    7. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. PMID: 25433291
    8. API5 acts as an immune escape gene in tumors by rendering them resistant to apoptosis triggered by tumor antigen-specific T cells. PMID: 24769442
    9. Low miR-224 and high API5 expression correlated with worse survival of glioblastoma patients. PMID: 24785373
    10. Api5, even if not physically interacting with E2F1, contributes positively to E2F1 transcriptional activity by increasing E2F1 binding to its target promoters. PMID: 23940755
    11. structure and function of API5 PMID: 22334682
    12. The prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients, was analysed. PMID: 20671611
    13. we infer that Pim-2 could activate API-5 to inhibit the apoptosis of liver cells, and NF-kappaB is the key regulator PMID: 19821157
    14. Apoptosis inhibitor-5/antiapoptosis clone-11 (Api5/Aac11) is a critical determinant of dE2F1-induced apoptosis in vivo and in vitro. PMID: 17112319
    15. define a true in vivo target of miR-224 and reaffirm the important role of miRNAs in the dysregulation of cellular processes that may ultimately lead to tumorigenesis PMID: 18319255
    16. The s report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. PMID: 19387494

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.; [Isoform 3]: Cytoplasm.
  • 蛋白家族：
    API5 family
  • 组织特异性：
    Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma
  • 数据库链接：

    HGNC: 594

    OMIM: 609774

    KEGG: hsa:8539

    STRING: 9606.ENSP00000431391

    UniGene: Hs.435771