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APOBEC1 Antibody

  • 货号：
    CSB-PA001919LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA001919LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) APOBEC1 Polyclonal antibody
  • Uniprot No.：
    P41238
  • 基因名：
    APOBEC1
  • 别名：
    ABEC1_HUMAN antibody; APOBEC 1 antibody; APOBEC1 antibody; Apolipoprotein B mRNA editing enzyme antibody; Apolipoprotein B mRNA editing enzyme catalytic polypeptide 1 antibody; Apolipoprotein B mRNA editing enzyme complex 1 antibody; Apolipoprotein B mRNA-editing enzyme 1 antibody; BEDP antibody; C->U-editing enzyme APOBEC-1 antibody; CDAR1 antibody; EC 3.5.4. antibody; HEPR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human C->U-editing enzyme APOBEC-1 protein (1-172AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，APOBEC1 Antibody (CSB-PA001919LA01HU)，的标记方式是Non-conjugated。对于APOBEC1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001919LB01HU APOBEC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA001919LC01HU APOBEC1 Antibody, FITC conjugated
    Biotin CSB-PA001919LD01HU APOBEC1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
  • 基因功能参考文献：
    1. Our findings propose APOBEC1 and isoform b as the potential endogenous mutators implicated in cancer in-frame indels and pave the way for their use as novel prognostic tumor markers. PMID: 29346513
    2. Luciferase-fused 3' untranslated region of human Dickkopf1 activity was highly upregulated in A1CF-overexpressed MCF7 cells, but this upregulation can be inhibited by mutating conserved binding motifs of Dickkopf1 3' untranslated region. A1CF played a crucial role in cell migration and survival through affecting 3' untranslated region of Dickkopf1 to upregulate its expression in MCF7 cells. PMID: 28639893
    3. AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review) PMID: 26398702
    4. Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models. PMID: 25085003
    5. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in esophageal squamous cell carcinoma. PMID: 25839328
    6. hnRNPQ6 is required for APOBEC1-enhanced IL8 production. PMID: 25100733
    7. Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4). PMID: 19911124
    8. The hypermutation activity of APOBEC-1 was decreased to background levels by a single point APOBEC-1 mutation of P29F or E181Q, while 50% of wild-type control editing at the normal site was retained. PMID: 20348446
    9. The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 with ACF might be operational during enterocyte differentiation. PMID: 19932086
    10. expression of two proteins essential for apolipoprotein B mRNA editing from a single gene through alternative splicing PMID: 11815617
    11. determination of multifunctional cycle and suppression of nonsense-mediated decay PMID: 12881431
    12. apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling PMID: 12896982
    13. apobec-1-mediated apoB mRNA editing is regulated by BAG-4 PMID: 14559896
    14. Expression of Apobec1 in HepG2 cells resulted in apoB mRNA editing, leading to decreased apoB100 abundance (to 6% of control) and the appearance of apoB48. PMID: 15979078
    15. APOBEC3G is not a nucleo-cytoplasmic shuttling protein like APOBEC-1 and activation-induced cytidine deaminase PMID: 16999936
    16. No evidence of association of APOBEC1 and PPARG with gallstone susceptibility was detected. PMID: 17696929
    17. Demonstrates the presence of a 36-aa peptide (isoform 2) derived from this gene in adult small intestinal villi using immunocytochemical analysis. PMID: 9186903

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cytidine and deoxycytidylate deaminase family
  • 组织特异性：
    Expressed exclusively in the small intestine.
  • 数据库链接：

    HGNC: 604

    OMIM: 600130

    KEGG: hsa:339

    STRING: 9606.ENSP00000229304

    UniGene: Hs.560